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The legacy of critical illness leaves millions of survivors worldwide with long lasting deficits in physical and brain function as well as anxiety, depression and post-traumatic stress disorder. Early rehabilitation in the intensive care unit (ICU) may prevent or minimize these effects. Amy M. Pastva, PT, MA, PhD, is collaborating with a global team from the University of Melbourne/Austin Health, Australia (Sue Berney, PT PhD, and Linda Denehy, PT, PhD), Royal Brisbane and Women’s Hospital, Australia (Jennifer Paratz, PT, PhD), and Johns Hopkins University, USA (Dale Needham, MD, PhD), to study the effectiveness of functional electrical stimulation of leg muscles during in-bed cycling (eStimCycle) on muscle bulk, strength, physical function and brain function at hospital discharge and at 6 and 12 months afterward in patients who were critically ill in the ICU (ClinicalTrials.gov ID: NCT02214823). This is one of the first of global studies in critical care rehabilitation and the combined effort will help guide treatment strategies worldwide for patients at high-risk for ICU-acquired deficits.