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Basic and Translational Research

Benjamin A. Alman, MD
Chair of Orthopaedic Surgery
James R. Urbaniak, MD, Professor of Orthopaedic Surgery
Professor in Cell Biology
Professor in Pediatrics
Professor in the Department of Pathology
Dr. Alman’s research focuses on understanding the role of developmentally important processes involving the musculoskeletal system in order to identify improved therapeutic approaches to orthopaedic pathologic disorders.

Samuel B. Adams, MD
Assistant Professor in Orthopaedic Surgery
Dr. Adams’s research focuses on post-traumatic ankle arthritis.

 

 

Gurpreet Baht, PhD
Assistant Professor in Orthopaedic Surgery
Dr. Baht's research focuses on investigating bone fracture repair and the influences age, inflammation, and metabolic syndromes play in tissue regeneration.

 

Jun Chen, PhD
Associate Professor in Orthopaedic Surgery
Dr. Chen’s research focuses on intervertebral disc (IVD) cell biology and the biological basis for IVD degeneration and herniation.        

 

Chad Cook, PT, PhD
Professor in Orthopaedic Surgery (Division of Physical Therapy)
Dr. Cook is a musculoskeletal clinical researcher with foci in diagnosis, interventions, and outcomes assessment.

 

Louis E. DeFrate, PhD
Frank H. Bassett III, MD Chair of Orthopaedic Surgery
Associate Professor in Orthopaedic Surgery
Assistant Professor in Biomedical Engineering

 

William C. Eward, DVM, MD
Assistant Professor in Orthopaedic Surgery

 

 

 

Adam Goode, PT, DPT, PhD
Assistant Professor in Orthopaedic Surgery (Division of Physical Therapy)

 

 

 

Matthew J. Hilton, PhD
Associate Professor in Orthopaedic Surgery
Associate Professor in Cell Biology
The Hilton Lab’s research focus includes programs in skeletal development, skeletal disease, and skeletal injury, repair, and regeneration.

 

Courtney Karner, PhD
Assistant Professor in Orthopaedic Surgery
Dr. Karner is engaged in research to understand the molecular underpinnings of cellular differentiation.

 

Virginia B. Kraus, MD, PhD
Professor of Medicine

 

 

 

Michel D. Landry, BScPT, PhD
Chief, Duke Doctor of Physical Therapy Division
Associate Professor in Orthopaedic Surgery (Division of Physical Therapy)

 

 

 

Amy McNulty, PhD
Assistant Professor in Orthopaedic Surgery
Assistant Professor in Pathology
The long-term goals of the McNulty Lab are to develop strategies to prevent osteoarthritis and to promote tissue repair and regeneration following joint injury.

 

Steven A. Olson, MD
Professor in Orthopaedic Surgery

 

 

 

Amy M. Pastva, PT, MA, PhD
Assistant Professor in Orthopaedic Surgery (Division of Physical Therapy)
Assistant Professor in Medicine
Assistant Research Professor in Cell Biology
Senior Fellow, Duke Center for the Study of Aging and Human Development
Dr. Pastva’s current scholarly pursuits include rehabilitation strategies for improving the health and function of individuals living with chronic diseases and/or surviving critical illness.

Michael P. Reiman, PT, DPT, OCS, SCS, ATC, FAAOMPT, CSCS
Assistant Professor in Orthopaedic Surgery (Division of Physical Therapy)
Dr. Reiman’s research involves orthopaedic examination and treatment, primarily of the hip joint and spine.

 

Jonathan C. Riboh, MD
Assistant Professor in Orthopaedic Surgery
Dr. Riboh's laboratory work focuses on building new biologic treatments to improve or even replace current surgical techniques, with the ultimate goal of getting athletes of all levels back in the game sooner.

 

Thorsten M. Seyler, MD
Assistant Professor in Orthopaedic Surgery
The Seyler Lab focuses on periprosthetic joint infections, a serious complication after hip and knee arthroplasty.

 

Shyni Varghese, PhD
Professor of Orthopaedic Surgery
Professor in the Department of Biomedical Engineering
Professor in the Department of Mechanical Engineering and Materials Science
Affiliate of the Regeneration Next Initiative

Our research lies at the interface of cell and molecular biology, engineering, physical sciences, material science, and medicine. Specifically, we are interested in understanding the effect of physicochemical cues of the microenvironment on various cellular behaviors leading to stem cell commitment, tissue repair and homeostasis, or disease progression.

Colleen Wu, PhD
Assistant Professor in Orthopaedic Surgery
Using a combination of in vivo mouse models and in vitro cell culture systems, our lab studies how low oxygen tension (hypoxia), in the bone microenvironment influences bone homeostasis, hematopoietic development, and metastatic bone colonization.