Thorsten M. Seyler, MD, PhD, Assistant Professor of Orthopaedic Surgery at Duke University, was recently recognized as an Expertscape World Expert in Replacement Arthroplasty . Dr. Seyler received this label for being in the top 0.1% of scholars writing about Joint Arthroplasty over the past 10 years.
The Seyler Lab focuses on periprosthetic joint infections, a serious complication after hip and knee arthroplasty. The incidence of periprosthetic joint infection (PJI) is reported to range from 2.0-2.4% of cases and is on the rise in the United States, as are the annual cases and cost of infected total joint arthroplasty revisions. An analysis of the National Inpatient Sample database found that PJI was the most common reason for revision total knee arthroplasty and the third most common diagnosis for revision total hip arthroplasty procedures
With the increased use of implantable devices such as total joint arthroplasties, the number of biofilm-associated infections has emerged as a significant financial burden and clinical problem because biofilms are often resistant to traditional antimicrobial therapy and difficult to eradicate. Biofilm cells show as much as a 1,000-fold more resistance to traditional antimicrobial therapy than their planktonic cell counterparts, and biofilm-based microbial infections make up up to 80% of all infections in patients, leading the CDC to declare biofilms to be one of the most important medical hurdles of the century.
Periprosthetic joint infections represent a major challenge to the total joint surgeon, and this epidemiologic health problem consumes significant resources for prevention, diagnosis, and management. The focus of the Seyler Lab is biofilm research associated with PJI. The lab's multidisciplinary biofilm research initiative aims to advance the understanding of the formation of biofilms and the ability to diagnose biofilm-associated infections, and to develop/use novel treatment approaches to prevent and treat biofilm-associated infections.
Expertscape is designed to help find the most knowledgeable physicians and health professionals in the world. Expertscape objectively ranks people and institutions by their expertise in more than 27,000 biomedical topics. The experts listed by Expertscape are those who have demonstrated their expertise and knowledge of a field by writing articles that are published in the medical literature. These are the experts who try to teach the world their knowledge.
The experts are ranked according to the quality and quantity of their publications. Expertscape examines all medical publications that are indexed in the National Library of Medicine's MEDLINE database. They rank the expertise of each author according to the number and type of articles that each expert has authored on the specific condition, disease, or treatment.
Congratulations to Dr. Seyler on this achievement!