Stay connected.      

  Make a Gift  

 

Basic and Translational Research

Benjamin A. Alman, MD
Chair of Orthopaedic Surgery
James R. Urbaniak, MD, Professor of Orthopaedic Surgery
Professor in Cell Biology
Professor in Pediatrics
Professor in the Department of Pathology

Dr. Alman’s research focuses on understanding the role of developmentally important processes involving the musculoskeletal system in order to identify improved therapeutic approaches to orthopaedic pathologic disorders.


Samuel B. Adams, MD
Assistant Professor in Orthopaedic Surgery

Dr. Adams’s research focuses on post-traumatic ankle arthritis.

 


Gurpreet Baht, PhD
Assistant Professor in Orthopaedic Surgery

Dr. Baht's research focuses on investigating bone fracture repair and the influences age, inflammation, and metabolic syndromes play in tissue regeneration.

 


Jun Chen, PhD
Associate Professor in Orthopaedic Surgery

Dr. Chen’s research focuses on intervertebral disc (IVD) cell biology and the biological basis for IVD degeneration and herniation.        


Chad Cook, PT, PhD
Professor in Orthopaedic Surgery (Division of Physical Therapy)

Dr. Cook is a musculoskeletal clinical researcher with foci in diagnosis, interventions, and outcomes assessment.


Louis E. DeFrate, PhD
Frank H. Bassett III, M. D. Associate Professor of Orthopaedic Surgery
Associate Professor in the Department of Mechanical Engineering and Material Science
Associate Professor in the Department of Biomedical Engineering
Affiliate of the Regeneration Next Initiative

The DeFrate laboratory applies engineering principles to study clinically-relevant problems involving the musculoskeletal system. In particular, they evaluate in vivo biomechanics using advanced radiographic and MRI techniques, which enables them to investigate soft tissue structure, composition, and function in healthy and diseased states.


William C. Eward, DVM, MD
Assistant Professor in Orthopaedic Surgery

Dr. Eward's laboratory focuses on comparative oncology -- the study of cancers from one species to another. Because sarcomas are rare in people but common in dogs, we attempt to learn as much as we can from every patient with a sarcoma, regardless of whether that patient walks on two legs or four.


Adam Goode, PT, DPT, PhD
Assistant Professor in Orthopaedic Surgery (Division of Physical Therapy)

His research interests are in lumbar spine degenerative changes, low back pain, and surgical outcomes and health services for cervical spine fusion.'


Matthew J. Hilton, PhD
Associate Professor in Orthopaedic Surgery
Associate Professor in Cell Biology

The Hilton Lab’s research focus includes programs in skeletal development, skeletal disease, and skeletal injury, repair, and regeneration.


Courtney Karner, PhD
Assistant Professor in Orthopaedic Surgery

Dr. Karner is engaged in research to understand the molecular underpinnings of cellular differentiation.


Virginia B. Kraus, MD, PhD
Professor of Medicine

The laboratory of Dr. V Kraus focuses on Osteoarthritis (OA) research. This laboratory studies the pathogenesis of A, the most prevalent of all forms of arthritis and the second greatest cause of disability worldwide. This group works to develop novel tools to aid in the diagnosis, prognosis, and effective intervention of the disease. The laboratory has ongoing basic research projects involving in vitro and animal model systems as well as biomedical clinical research and translational medicine trials in OA in humans. 


Michel D. Landry, BScPT, PhD
Professor in Orthopaedic Surgery 

Dr. Landry has spent much of his career as a health policy and health services researcher, where his focus has been on developing forecasting methodologies specific to rehabilitation health human resources across the continuum of care. 


Amy McNulty, PhD
Assistant Professor in Orthopaedic Surgery
Assistant Professor in Pathology

The long-term goals of the McNulty Lab are to develop strategies to prevent osteoarthritis and to promote tissue repair and regeneration following joint injury.


Steven A. Olson, MD
Professor in Orthopaedic Surgery

As an Orthopaedic Surgeon, Dr. Olson's primary focus of research is joint preservation. His primary clinical interests are Orthopaedic Trauma and Hip Reconstruction. 


Amy M. Pastva, PT, MA, PhD
Assistant Professor in Orthopaedic Surgery (Division of Physical Therapy)
Assistant Professor in Medicine
Assistant Research Professor in Cell Biology
Senior Fellow, Duke Center for the Study of Aging and Human Development

Dr. Pastva’s current scholarly pursuits include rehabilitation strategies for improving the health and function of individuals living with chronic diseases and/or surviving critical illness.


Michael P. Reiman, PT, DPT, OCS, SCS, ATC, FAAOMPT, CSCS
Assistant Professor in Orthopaedic Surgery (Division of Physical Therapy)

Dr. Reiman’s research involves orthopaedic examination and treatment, primarily of the hip joint and spine.


Jonathan C. Riboh, MD
Assistant Professor in Orthopaedic Surgery


Dr. Riboh's laboratory work focuses on building new biologic treatments to improve or even replace current surgical techniques, with the ultimate goal of getting athletes of all levels back in the game sooner.


Thorsten M. Seyler, MD
Assistant Professor in Orthopaedic Surgery

The Seyler Lab focuses on periprosthetic joint infections, a serious complication after hip and knee arthroplasty.


Shyni Varghese, PhD
Professor of Orthopaedic Surgery
Professor in the Department of Biomedical Engineering
Professor in the Department of Mechanical Engineering and Materials Science
Affiliate of the Regeneration Next Initiative


Our research lies at the interface of cell and molecular biology, engineering, physical sciences, material science, and medicine. Specifically, we are interested in understanding the effect of physicochemical cues of the microenvironment on various cellular behaviors leading to stem cell commitment, tissue repair and homeostasis, or disease progression.


Colleen Wu, PhD
Assistant Professor in Orthopaedic Surgery

Using a combination of in vivo mouse models and in vitro cell culture systems, our lab studies how low oxygen tension (hypoxia), in the bone microenvironment influences bone homeostasis, hematopoietic development, and metastatic bone colonization.