Basic and Translational Research


Alman for research

Benjamin A. Alman, MD
Chair of Orthopaedic Surgery
James R. Urbaniak, MD, Professor of Orthopaedic Surgery
Professor in Cell Biology
Professor in Pediatrics
Professor in the Department of Pathology
The Alman Lab

Dr. Alman’s research focuses on understanding the role of developmentally important processes involving the musculoskeletal system in order to identify improved therapeutic approaches to orthopaedic pathologic disorders.


adams for research

Samuel B. Adams, MD
Associate Professor in Orthopaedic Surgery
Samuel B. Adams Lab
Dr. Adams’s research focuses on post-traumatic ankle arthritis.
Adams Lab

Baht for Research

Gurpreet Baht, PhD
Assistant Professor in Orthopaedic Surgery
The Baht Lab

Dr. Baht's research focuses on investigating bone fracture repair and the influences age, inflammation, and metabolic syndromes play in tissue regeneration.

Todd Cade for Basic and Translational

W. Todd Cade, PT, PhD
Professor of Orthopaedic Surgery
Doctor of Physical Therapy Director and Division Chief

Dr. Cade's research in Exercise and Cardiometabolic Health aims to study mechanisms of and treatments (nutritional/exercise/pharmacologic/gene therapy) for abnormalities in cardiometabolic disease, focusing on substrate (e.g. amino acid, glucose, fatty acid) metabolism, energetic, and functional abnormalities in skeletal muscle, heart, adipose tissue, liver, and brain.


Joe Chakkalakal, PhD for Web

Joe Chakkalakal, PhD
Associate Professor in Orthopaedic Surgery and Cell Biology
Skeletal Muscle Regeneration and Disease Research
The Chakkalkal Lab

Dr. Chakkalakal's research utilizes murine models, injury paradigms, cell culture systems, imaging techniques, physiological assessment, and gene expression analysis to determine how specific cell populations and molecules of interest affect neuromuscular development, maintenance, and regeneration.


Chad Cook for Research

Chad Cook, PT, PhD
Professor in Orthopaedic Surgery (Division of Physical Therapy)

A musculoskeletal clinical researcher with foci in diagnosis, interventions, and outcomes assessment, Dr. Cook is the director of the Duke Center of Excellence in Manual and Manipulative Therapy.


DeFrate for Research

Louis E. DeFrate, PhD
Vice Chair Biomechanics, Movement, and Imaging Research
Professor in Orthopaedic Surgery
Professor in the Department of Mechanical Engineering and Material Science
Professor in the Department of Biomedical Engineering
Affiliate of the Regeneration Next Initiative
Musculoskeletal Bioengineering Laboratory

The DeFrate laboratory applies engineering principles to study clinically-relevant problems involving the musculoskeletal system. In particular, they evaluate in vivo biomechanics using advanced radiographic and MRI techniques, which enables them to investigate soft tissue structure, composition, and function in healthy and diseased states.


Eward for Research

William C. Eward, DVM, MD
Associate Professor in Orthopaedic Surgery

Dr. Eward's laboratory focuses on comparative oncology -- the study of cancers from one species to another. Because sarcomas are rare in people but common in dogs, we attempt to learn as much as we can from every patient with sarcoma, regardless of whether that patient walks on two legs or four.


Goode for Research

Adam Goode, PT, DPT, PhD
Associate Professor in Orthopaedic Surgery (Division of Physical Therapy)

Dr. Goode’s research interests are in lumbar spine degenerative changes, low back pain, and surgical outcomes and health services for cervical spine fusion.


M hilton research

Matthew J. Hilton, PhD
Associate Professor in Orthopaedic Surgery
Associate Professor in Cell Biology
Associate Chair for Research, Basic/Translational Sciences
The Hilton Lab

The Hilton Lab’s research focus includes programs in skeletal development, skeletal disease, and skeletal injury, repair, and regeneration.


Kraus Research

Virginia B. Kraus, MD, PhD
Professor of Medicine
The Kraus Lab

The laboratory of Dr. Kraus focuses on Osteoarthritis (OA) research. This laboratory studies the pathogenesis of A, the most prevalent of all forms of arthritis, and the second greatest cause of disability worldwide. This group works to develop novel tools to aid in the diagnosis, prognosis, and effective intervention of the disease. The laboratory has ongoing basic research projects involving in vitro and animal model systems as well as biomedical clinical research and translational medicine trials in OA in humans. 


McNulty for Research

Amy McNulty, PhD
Assistant Professor in Orthopaedic Surgery
Assistant Professor in Pathology
The McNulty Lab

The long-term goals of the McNulty Lab are to develop strategies to prevent osteoarthritis and to promote tissue repair and regeneration following joint injury.


Olson for research

Steven A. Olson, MD
Professor in Orthopaedic Surgery

As an Orthopaedic Surgeon, Dr. Olson’s primary focus of research is joint preservation. His primary clinical interests are Orthopaedic Trauma and Hip Reconstruction. 


Pastva for research

Amy M. Pastva, PT, MA, PhD
Associate Professor in Orthopaedic Surgery (Division of Physical Therapy)
Assistant Professor in Medicine
Assistant Research Professor in Cell Biology
Senior Fellow, Duke Center for the Study of Aging and Human Development
Dr. Pastva’s current scholarly pursuits include rehabilitation strategies for improving the health and function of individuals living with chronic diseases and/or surviving critical illness.


Reiman for Research

Michael P. Reiman, PT, DPT, OCS, SCS, ATC, FAAOMPT, CSCS
Assistant Professor in Orthopaedic Surgery (Division of Physical Therapy)

Dr. Reiman’s research involves orthopaedic examination and treatment, primarily of the hip joint and spine.


Seyler for research

Thorsten M. Seyler, MD
Associate Professor in Orthopaedic Surgery

The Seyler Lab focuses on periprosthetic joint infections, a serious complication after hip and knee arthroplasty.


Visgauss for research

Julia Visgauss, MD
Assistant Professor in Orthopaedic Surgery 

Dr. Visgauss focuses her research efforts on understanding what drives aggressive behavior and drug resistance in sarcoma. This is important because there are few drugs that are effective in treating sarcoma that has spread to other areas of the body. The goal is not only to better understand the biology of sarcoma but also to identify drugs that specifically target these areas to improve treatments and outcomes for patients.


Shyni for research

Shyni Varghese, PhD
Professor of Orthopaedic Surgery
Professor in the Department of Biomedical Engineering
Professor in the Department of Mechanical Engineering and Materials Science
Affiliate of the Regeneration Next Initiative

Our research lies at the interface of cell and molecular biology, engineering, physical sciences, material science, and medicine. Specifically, we are interested in understanding the effect of physicochemical cues of the microenvironment on various cellular behaviors leading to stem cell commitment, tissue repair, and homeostasis, or disease progression.


Colleen Wu for Research

Colleen Wu, PhD
Assistant Professor in Orthopaedic Surgery

Using a combination of in vivo mouse models and in vitro cell culture systems, our lab studies how low oxygen tension (hypoxia), in the bone microenvironment influences bone homeostasis, hematopoietic development, and metastatic bone colonization.


Xin Zhang 200x200

Xin Zhang, MD
Assistant Professor in Orthopaedic Surgery