Louis E. DeFrate, ScD

Vice Chair Biomechanics, Movement, and Imaging Research Department of Orthopaedic Surgery
Professor in the Department of Mechanical Engineering and Material Science
Professor in Orthopaedic Surgery
Professor in the Department of Biomedical Engineering
Affiliate of the Duke Regeneration Next Initiative

Lab Site: sites.duke.edu/defratelab/

The DeFrate laboratory applies engineering principles to study clinically-relevant problems involving the musculoskeletal system. In particular, they evaluate in vivo biomechanics using advanced radiographic and MRI techniques, which enables them to investigate soft tissue structure, composition, and function in healthy and diseased states.

Selected Publications and Grants

Publications

Grants

  • Mentoring in Musculoskeletal Pain Phenotypes (Collaborator), awarded by National Institutes of Health, administered by Orthopaedics, Physical Therapy, 2022-2027 More info
  • Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury (Co-Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2021-2026 More info
  • In Vivo Knee Motion and ACL Biomechanics During Dynamic Activities (Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
  • Mechanical Biomarkers of Chronic Low Back Pain (Co-Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
  • Weight loss, in vivo cartilage mechanics, and joint health (Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2023 More info
  • Quantitative MRI of Glenohumeral Cartilage & Labrum in Shoulder Instability (Co-Principal Investigator), awarded by Orthopaedic Research and Education Foundation, administered by Orthopaedics, 2022-2023 More info
  • Duke CTSA (TL1) Year 5 (Mentor), awarded by National Institutes of Health, administered by Institutes and Centers, 2018-2023 More info
  • Metabolomic & Radiographic Markers of Fracture Risk Among Older Adults with Diabetes (K23) (Co-Mentor), awarded by National Institutes of Health, administered by Medicine, Endocrinology, Metabolism, and Nutrition, 2018-2023 More info
  • Development of Chondroregenerative Therapy for Human Osteoarthritis (Principal Investigator), awarded by University of Rochester Medical Center, administered by Orthopaedics, 2017-2022 More info
  • Exercise-induced recovery of intervertebral disc health (Collaborator), awarded by National Institutes of Health, administered by Orthopaedics, 2020-2022 More info

Contact

Medical Sciences Research Building I, 203 Research Drive, Room 379
DUMC Box 3093, Durham, NC 27710
919-681-9959
lou.defrate@duke.edu