Virginia B. Kraus, MD, PhD

Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative

My special area of expertise is as a clinician-scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Selected Publications and Grants

Publications

Grants

  • Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers (Principal Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2021-2025 More info
  • Behavior and Physiology in Aging (Mentor), awarded by National Institutes of Health, administered by Center for the Study of Aging and Human Development, 2015-2025 More info
  • Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic Health (Co Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2021-2025 More info
  • Mechanical Biomarkers of Chronic Low Back Pain (Co Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
  • Weight loss, in vivo cartilage mechanics, and joint health (Co Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2023 More info
  • Exercise Induced Muscle Secreted Factors That Modify Osteoarthritis (OA) Severity (Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2021-2023 More info
  • Epigenetic Mechanisms Promoting Longevity (Principal Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2018-2023 More info
  • Development of an Early Osteoarthritis Diagnostic Panel via a Proteomic Approach (Principal Investigator), awarded by Zimmer Biomet Company, administered by Duke Molecular Physiology Institute, 2018-2022 More info
  • Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) (Investigator), awarded by National Institutes of Health, administered by Center for the Study of Aging and Human Development, 2017-2022 More info
  • Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk) (Co Investigator), awarded by National Institutes of Health, administered by Duke Clinical Research Institute, 2017-2022 More info

 

Contact

300 N. Duke Street
Carmichael Building Room 15-205, Durham, NC 27701
Duke Box 104775, Durham, NC 27701
919-681-6652
vbk@duke.edu