The Seyler Laboratory

Grants

• G7® Acetabular System Clinical TrialPrincipal Investigator · Awarded by Zimmer Biomet Company · 2021 - 2024
   
• Perioperative Antibiotic Prophylaxis in Patients Undergoing Elective TJA ResearchPrincipal Investigator · Awarded by Orthopaedic Research and Education Foundation · 2019 - 2024
   
• ARRAY: A novel polymeric mesh for prophylactic antibiotic protection of cardiac implantable electronic devices ResearchPrincipal Investigator · Awarded by 21MedTech, LLC · 2023 - 2024
   
• A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform Clinical TrialInvestigator · Awarded by Zimmer Biomet Company · 2019 - 2023
   
• Surgical Risk Prediction, Performance, and Scheduling Suite ResearchPrincipal Investigator · Awarded by Piedmont Orthopedic Foundation · 2021 - 2022

• A Permanent Articulating Spacer Versus Two-Stage Exchange for Chronic Periprosthetic Joint Infection: A Propensity Score-Matched Study. Journal Article J Arthroplasty · August 2023
  BACKGROUND: Although 2-stage revision has been proposed as gold standard for periprosthetic joint infection treatment, limited evidence exists for articulating spacers as definitive management. The purpose of this study was to compare clinical ...Full text
   
• Cutibacterium positive cultures in total joint arthroplasty: a comparison of the hip, knee, and shoulder. Journal Article Int Orthop · August 2023PURPOSE: Cutibacterium spp. (formerly Propionibacterium) is a slow-growing, Gram-positive, anaerobic bacteria and is an emerging clinical entity in prosthetic joint infection (PJI). This study compares the presentation, surgical management, and post-operative ...Full text
   
• Trends in Total Knee Arthroplasty Cementing Technique Among Arthroplasty Surgeons Survey of the American Association of Hip and Knee Surgeons Members. Journal Article J Arthroplasty · July 2023
  BACKGROUND: Aseptic loosening persists as one of the leading causes of failure following cemented primary total knee arthroplasty (TKA). Cement technique may impact implant fixation. We hypothesized that there is variability in TKA cement technique among a ...Full text
   
• The Removal of Total Hip Arthroplasty From the Inpatient-Only List has Improved Patient Selection and Expanded Optimization Efforts. Journal Article J Arthroplasty · July 2023
  BACKGROUND: On January 1, 2020, the Centers for Medicare and Medicaid Services removed total hip arthroplasty (THA) from the Inpatient-Only (IPO) list. This study evaluated patient demographics and comorbidities, preoperative optimization efforts, and 30-d ...Full text
   
• Does Preoperative Weight Loss Within 6 Months or 1 Year Change the Risk of Adverse Outcomes in Total Knee Arthroplasty by Initial Body Mass Index Classification? Journal Article J Arthroplasty · June 16, 2023BACKGROUND: High body mass index (BMI) is associated with adverse outcomes after total knee arthroplasty (TKA). Thus, many patients are advised to lose weight before TKA. This study examined how weight loss before TKA is associated with adverse outcomes de ...Full text
   
• An ACS-NSQIP Analysis of Unicompartmental Knee Arthroplasty Trends from 2013 to 2018. Journal Article J Knee Surg · June 2023Unicompartmental knee arthroplasty (UKA) volume has increased with advances in implant design, perioperative protocols, and patient selection. This study analyzed national trends of UKA from 2013 to 2018 and the relationship between patient demographics an ...Full text
   
• Evaluation of anterior translation in total knee arthroplasty utilizing stress radiographs. Journal Article J Orthop Surg Res · June 1, 2023
  BACKGROUND: Flexion instability is a common cause for revision after total knee arthroplasty (TKA); however, little objective criteria exist to determine excessive laxity in flexion. This study sought to determine the reliability of stress radiographs for ...Full text
   
• Projections and Epidemiology of Revision Hip and Knee Arthroplasty in the United States to 2040-2060 Journal Article Arthroplasty Today · June 1, 2023Background: National projections of future joint arthroplasties help understand the changing burden of surgery and related outcomes on the health system. This study aims to update the literature by producing Medicare projections for re ...Full text
• Failed 2-Stage Revision Knee Arthroplasty for Periprosthetic Joint Infection-Patient Characteristics and Outcomes. Journal Article J Arthroplasty · May 12, 2023BACKGROUND: Chronic prosthetic joint infection (PJI) is most frequently treated with 2-stage revision and antibiotic treatment. The aims of this study were 1) to investigate the characteristics of patients who have recurrent infection follo ...Full text
   
• The Practice Patterns of American Association of Hip and Knee Surgeons for the Management of Chronic Periprosthetic Joint Infection After Total Knee Arthroplasty. Journal Article J Arthroplasty · May 2, 2023BACKGROUND: The management of periprosthetic joint infection (PJI) following total knee arthroplasty (TKA) has considerable variation. To better capture current preferences for the management of PJI, this study sought to poll the current members  ...Full text
   
• A Validated Pre-operative Risk Prediction Tool for Extended Inpatient Length of Stay Following Primary Total Hip or Knee Arthroplasty. Journal Article J Arthroplasty · May 2023
  BACKGROUND: As value-based reimbursement models mature, understanding the potential trade-off between inpatient lengths of stay and complications or need for costly post-acute care becomes more pressing. Understanding and predicting a patient's expected bas ...Full text
   
• D-Dimer, Erythrocyte Sedimentation Rate, and C-Reactive Protein Sensitivities for Periprosthetic Joint Infection Diagnosis.Journal Article J Arthroplasty · May 2023
  BACKGROUND: There is contradicting evidence on the diagnostic value of inflammatory biomarkers for periprosthetic joint infection (PJI). We sought to quantify the sensitivity of D-dimer for acute and chronic PJI diagnosis and evaluate D-dimer lab values in ...Full text
   
• A Multicenter Prospective Investigation on Patient Physical and Mental Health After Girdlestone Resection Arthroplasty. Journal Article J Arthroplasty · May 2023BACKGROUND: Girdlestone resection arthroplasty is a salvage procedure for hip periprosthetic joint infection (PJI) that controls infection and reduces chronic pain but may result in limited postoperative joint function. This study aimed to assess ...Full text
   
• Opioid Legislation Decreases Opioid Prescribing in Total Knee Arthroplasty. Journal Article Orthopedics · May 2023The purpose of this study was to evaluate the impact of opioid-limiting legislation on perioperative opioid prescriptions in total knee arthroplasty. The hypothesis was that opioid legislation has reduced opioid prescription filling above levels anticipated...Full text
   
• Outcome Disparities in Total Knee and Total Hip Arthroplasty among Native American Populations. Journal Article J Racial Ethn Health Disparities · April 10, 2023
  BACKGROUND: No prior racial disparities studies in total knee arthroplasty (TKA) and total hip arthroplasty (THA) have specifically evaluated outcomes among American Indian or Alaska Native (AIAN) patients. We hypothesized that AIAN patients have worse out ...Full text
   
• Accelerated Discharge After Aseptic Revision Total Hip Arthroplasty Does Not Predict Inferior 30-Day Outcomes. Journal Article J Arthroplasty · March 2023
  BACKGROUND: Perioperative advancements have made outpatient primary total hip arthroplasty (THA) a viable option for patients. This study evaluated the feasibility of expedited discharge after revision THA and compared 30-day outcomes to patients who had p ...Full text
   
• Direct Costs Vary by Outcome in Two-Stage Revision Arthroplasty for the Treatment of Hip Periprosthetic Joint Infection. Journal Article Arthroplast Today · February 2023
  BACKGROUND: Two-stage revision arthroplasty is the gold standard for treating chronic prosthetic joint infection (PJI), but there has been limited analysis of the costs incurred beyond the index procedure and how additional complications and/or surgeries i ...Full text
   
• Routine Pathologic Examination of the Femoral Head in Total Hip Arthroplasty: A Survey Study of the American Association of Hip and Knee Surgeons. Journal Article Arthroplast Today · February 2023
  BACKGROUND: Current literature does not provide conclusive evidence on whether routine pathologic examination of femoral heads from total hip arthroplasty is indicated or cost-effective. As a result, there is substantial variation in opinion among surgeons ...Full text
   
• Do Patients with Paget's Disease Have Worse Outcomes Following Primary Total Knee Arthroplasty? Journal Article J Knee Surg · January 2023
  Well-powered studies evaluating the effects of Paget's disease on patient outcomes following primary total knee arthroplasty (TKA) are limited. The objective of this study was to determine whether Paget's disease patients undergoing primary TKA have higher ...Full text
   
• Cost Drivers in Two-Stage Treatment of Hip Periprosthetic Joint Infection With an Antibiotic Coated Cement Hip Spacer.Journal Article J Arthroplasty · January 2023
  BACKGROUND: The current gold standard for treating chronic Periprosthetic Joint Infection (PJI) is a 2-stage revision arthroplasty. There has been little investigation into what specific patient and operative factors may be able to predict higher costs of ...Full text

If you would like to join the team, please contact Dr. Seyler.

• Best Poster Award Primary Knee Category 25th Annual Meeting AAHKS National AAHKS · November 2016 – Lingering Risk: Bariatric Surgery Before Total Knee Arthroplasty
   
• Young Investigator Award National The Hip Society · 2014 – Impact of Lumbar Arthrodesis on Outcomes After Elective Total Hip Arthroplasty
   
• Annual Meeting Scientific Exhibit Award of Excellence – National American Academy of Orthopaedic Surgeons · 2009