Our research is focused on developing translational solutions to regenerate bone after injury and prevent complications. We utilize clinically applicable methodology to develop and analyze new technologies to improve fracture care for all populations, focusing first on the most vulnerable communities.

Grants

• Fresh Tissue Lab Inst. Training Prgm or CMEPrincipal Investigator · Awarded by CurvaFix, Inc. · 2022 - 2023
   
• Fresh Tissue Lab Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Medical Device Business Services, Inc. · 2022 - 2022
   
• Fresh Tissue Lab Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Si-Bone Inc. · 2022 - 2022

Selected Publications

• Intramedullary Nails vs Open Reduction in Internal Fixation for Humeral Shaft Fractures: A Meta-Analysis of Randomized Control Trials. Journal Article J Shoulder Elbow Surg · August 12, 2023
  PURPOSE: The purpose of this study was to perform a meta-analysis of randomized controlled trials (RCTs) to compare outcomes following intramedullary nailing (IMN) vs. open reduction and internal fixation (ORIF) of humeral shaft fractures. METHODS: A liter ...Full text
   
• Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission. Journal Article Lancet Haematol · August 2023 Full text
   
• Toward Automated Detection of Silent Cerebral Infarcts in Children and Young Adults With Sickle Cell Anemia. Journal Article Stroke · August 2023BACKGROUND: Silent cerebral infarcts (SCI) in sickle cell anemia (SCA) are associated with future strokes and cognitive impairment, warranting early diagnosis and treatment. Detection of SCI, however, is limited by their small size, especially when neurora ...Full text
   
• Barriers and Facilitators of Premarital Genetic Counseling for Sickle Cell Disease in Northern Nigeria. Journal Article J Pediatr Hematol Oncol · August 1, 2023In high-income countries, premarital genetic counseling for Sickle Cell Disease (SCD) is a standard practice. However, in Nigeria, no formal premarital genetic counseling program is available for SCD. We conducted a series of focus group discussions ...Full text
   
• Drilling the cement mantle in well-fixed periprosthetic femur fractures is not associated with arthroplasty-related complications. Journal Article Eur J Orthop Surg Traumatol · July 2023
  OBJECTIVE: To determine if screw fixation across a cement mantle is safe and effective during plate fixation of well-fixed periprosthetic femur fractures. DESIGN: Retrospective cohort study. SETTING: Academic Level I Trauma Center. PATIENTS: Twenty-eight p ...Full text
   
• Updated Blocking Techniques for Lower Extremity Medullary Nailing: Beyond the Concavity of Deformity. Journal Article J Am Acad Orthop Surg · July 1, 2023
  Modern blocking techniques are helpful in achieving anatomic alignment and stable fixation during end-segment nailing. Whether with screws or drill bits, blocking implants can correct both angular and translational deformities. Understanding the biomechanics ...Full text
   
• Peripheral Nerve Block Delays Mobility and Increases Length of Stay in Patients With Geriatric Hip Fracture. Journal Article J Am Acad Orthop Surg · June 15, 2023INTRODUCTION: Peripheral nerve blocks (PNB) has been increasingly used in the care of patients with geriatric hip fracture to reduce perioperative opiate use and the need for general anesthesia. However, the associated motor palsy may impair patients' abil ...Full text
   
• Underweight children older than five years with sickle cell anemia are at risk for early mortality in a low-resource setting. Journal Article Blood Adv · June 13, 2023Undernutrition is a risk factor for under-5 mortality. It is also postulated to be a risk factor for mortality in older children and adults with sickle cell anemia (SCA). We tested the hypothesis that underweight is associated with mortality in children ag ...Full text
   
• Robotic-Assisted Minimally Invasive Spinopelvic Fixation for Traumatic Sacral Fractures: Case Series Investigating Early Safety and Efficacy. Journal Article World Neurosurg · June 12, 2023
  BACKGROUND: High-energy traumatic sacral fractures may lead to significant functional deficits, particularly U-type or AOSpine classification type C fractures. Traditionally, spinopelvic fixation for unstable sacral fractures was performed with open reduc ...Full text
   
• Type III Open Tibia Fractures Treated With Single-Stage Immediate Medullary Nailing and Attempted Primary Closure Yield Low Rates of Flap Coverage. Journal Article J Am Acad Orthop Surg · March 1, 2023
  OBJECTIVE: This study aimed to determine whether type III open high-energy tibia fractures treated with immediate intramedullary nailing (IMN) and primary closure yield low rates of flap coverage. METHODS: Patients with high-energy type IIIA o ...Full text
   
• Hydroxyurea for secondary stroke prevention in children with sickle cell anemia in Nigeria: a randomized controlled trial. Journal Article Blood · February 23, 2023
  We tested the hypothesis that fixed oral moderate-dose hydroxyurea (20 mg/kg per day) for initial treatment of secondary stroke prevention results in an 80% relative risk reduction of stroke or death when compared with fixed oral low-dose hydroxyurea (10 m ...Full text
   
• Use of a Six-Item Modified Frailty Index to Predict 30-day Adverse Events, Readmission, and Mortality in Older Patients Undergoing Surgical Fixation of Lower Extremity, Pelvic, and Acetabular Fractures. Journal Article J Am Acad Orthop Surg Glob Res Rev · January 1, 2023INTRODUCTION: This is a retrospective study evaluating the use of a new six-item modified frailty index (MF-6) to predict short-term outcomes of patients receiving surgery for lower extremity fractures. METHODS: Patients older than 65 years undergoing open ...Full text
   
• Silent infarction in sickle cell disease is associated with brain volume loss in excess of infarct volume Journal Article Frontiers in Neurology · January 1, 2023Introduction: Sickle cell disease (SCD) increases cerebral infarct risk, but reported effects on brain volume have varied. More detailed information using larger cohorts and contemporary methods could motivate the use of longitudinal brain volume assessments...Full text
   
• Increasing access to quality healthcare for children who are incarcerated: American Pediatrics Society issue of the year (2023–2024) Journal Article Pediatric Research · January 1, 2023 Full text
   
• A Single Proximal Interlocking Bolt May Be Sufficient for Retrograde Nailing of Extra-articular Femur Fractures. Journal Article J Orthop Trauma · December 1, 2022
  OBJECTIVE: To evaluate whether a single proximal interlocking bolt was sufficient to treat extra-articular femur fractures with retrograde medullary nailing. DESIGN: Retrospective comparative study. SETTING: Academic Level 1 trauma center...Full text
   
• Is the timing of fixation associated with fracture-related infection among tibial plateau fracture patients with compartment syndrome? A multicenter retrospective cohort study of 729 patients. Journal Article Injury · November 2022
  BACKGROUND: Tibial plateau fractures with an ipsilateral compartment syndrome are a clinical challenge with limited guidance regarding the best time to perform open reduction and internal fixation (ORIF) relative to fasciotomy wound closure. This study aim ...Full text
   
• Effect of Blood Transfusion on Cerebral Hemodynamics and Vascular Topology Described by Computational Fluid Dynamics in Sickle Cell Disease Patients Journal Article Brain Sciences · October 1, 2022
  The main objective of this study was to demonstrate that computational fluid dynamics (CFD) modeling can be used to study the contribution of covert and overt vascular architecture to the risk for cerebrovascular disease in sickle cell disease (SCD) and to ...Full tex
   
• Short versus long cephalomedullary nailing of intertrochanteric fractures: a meta-analysis of 3208 patients Journal Article Archives of Orthopaedic and Trauma Surgery · July 2022 Full text
   
• A bioactive synthetic membrane improves bone healing in a preclinical nonunion model. Journal Article Injury · April 2022OBJECTIVES: High energy long bone fractures with critical bone loss are at risk for nonunion without strategic intervention. We hypothesize that a synthetic membrane implanted at a single stage improves bone healing in a preclinical nonunion model. METHODS ...Full text
• Mini-fragment plating of olecranon fractures is comparable to pre-contoured small-fragment plating Journal Article Journal of Orthopaedics · March 2022 Full text

If you would like to join the Debaun Lab team, contact malcolm.debaun@duke.edu.