Lab site: https://sites.google.com/view/thebahtlab/home
Gurpreet Baht, Ph.D., is an Assistant Professor in the Department of Orthopaedic Surgery and a faculty member of the Duke Institute of Molecular Physiology. Dr. Baht’s work focuses on bone health, specifically understanding fracture repair in the context of aging.
Tissue repair and regeneration diminish with age. In the elderly, bone repair in response to injury occurs at a slower pace with deposition of extraneous tissue. A number of molecular and cellular processes have been implicated in aging fracture repair. Dr. Baht utilizes mouse models and tissue culture techniques to investigate fracture repair and aging.
Current Projects
- Investigating bone fracture repair and the influences age, inflammation, and metabolic syndromes play in tissue regeneration.
Selected Publications & Grants
Publications
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Huang, Rong, Abhinav R. Balu, Kristin H. Molitoris, James P. White, Alexander G. Robling, Ugur M. Ayturk, and Gurpreet S. Baht. “The role of Meteorin-like in skeletal development and bone fracture healing.” J Orthop Res, January 25, 2022. https://doi.org/10.1002/jor.25286.
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Alman, Benjamin, and Gurpreet Baht. “Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton.,” 2230:105–13, 2021. https://doi.org/10.1007/978-1-0716-1028-2_7.
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Huang, Rong, Linda Vi, Xiaohua Zong, and Gurpreet Baht. “Maresin 1 resolves macrophage inflammation to improve aged bone fracture healing.” In Journal of Bone and Mineral Research, 35:163–163, 2020.
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Huang, Rong, Linda Vi, Xiaohua Zong, and Gurpreet S. Baht. “Maresin 1 resolves aged-associated macrophage inflammation to improve bone regeneration.” Faseb J 34, no. 10 (October 2020): 13521–32. https://doi.org/10.1096/fj.202001145R.
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Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nature Metabolism 2, no. 8 (August 2020): 794. https://doi.org/10.1038/s42255-020-0257-y.
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Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 3 (March 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.
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Zeng, Yuze, Yu-Ru V. Shih, Gurpreet S. Baht, and Shyni Varghese. “In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.” Adv Mater 32, no. 8 (February 2020): e1906022. https://doi.org/10.1002/adma.201906022.
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Miller-Rhodes, Patrick, Cuicui Kong, Gurpreet S. Baht, Priyanka Saminathan, Ramona M. Rodriguiz, William C. Wetsel, Harris A. Gelbard, and Niccolò Terrando. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.” J Neuroinflammation 16, no. 1 (October 28, 2019): 193. https://doi.org/10.1186/s12974-019-1582-5.
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Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing.” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.
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Miller-Rhodes, Patrick, Cuicui Kong, Gurpreet Baht, Ramona Rodriguiz, William Wetsel, Harris Gelbard, and Niccolò Terrando. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders,” February 2019. https://doi.org/10.1101/537472.
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Vi, Linda, Gurpreet S. Baht, Erik J. Soderblom, Heather Whetstone, Qingxia Wei, Bridgette Furman, Vijitha Puviindran, et al. “Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.” Nat Commun 9, no. 1 (December 5, 2018): 5191. https://doi.org/10.1038/s41467-018-07666-0.
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Zong, Xiaohua, Puviindran Nadesan, James White, Phillip White, and Gurpreet Baht. “The role of apolipoprotein E in fracture healing and osteoblast differentiation.” In Journal of Bone and Mineral Research, 33:9–9. WILEY, 2018.
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Baht, Gurpreet S., Linda Vi, and Benjamin A. Alman. “The Role of the Immune Cells in Fracture Healing.” Curr Osteoporos Rep 16, no. 2 (April 2018): 138–45. https://doi.org/10.1007/s11914-018-0423-2.
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Xiong, Chao, Zhiquan Zhang, Gurpreet S. Baht, and Niccolo Terrando. “A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration.” J Vis Exp, no. 132 (February 27, 2018). https://doi.org/10.3791/56701.
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Nadesan, Puviindran, and Gurpreet Baht. “A Role for Apolipoprotein E in Fracture Healing.” In Journal of Bone and Mineral Research, 32:S125–26. WILEY, 2017.
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Baht, Gurpreet S., Puviindran Nadesan, David Silkstone, and Benjamin A. Alman. “Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair.” Bone 98 (May 2017): 31–36. https://doi.org/10.1016/j.bone.2017.02.012.
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Ng, Adeline H., Gurpreet S. Baht, Benjamin A. Alman, and Marc D. Grynpas. “Bone Marrow Stress Decreases Osteogenic Progenitors.” Calcif Tissue Int 97, no. 5 (November 2015): 476–86. https://doi.org/10.1007/s00223-015-0032-3.
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Baht, Gurpreet S., David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei, and Benjamin A. Alman. “Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin.” Nat Commun 6 (August 26, 2015): 7761. https://doi.org/10.1038/ncomms8761.
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Vi, Linda, Gurpreet S. Baht, Heather Whetstone, Adeline Ng, Qingxia Wei, Raymond Poon, Sivakami Mylvaganam, Marc Grynpas, and Benjamin A. Alman. “Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.” J Bone Miner Res 30, no. 6 (June 2015): 1090–1102. https://doi.org/10.1002/jbmr.2422.
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Baht, Gurpreet S., David Silkstone, Linda Vi, Puviindran Nadesan, Yasha Amani, Heather Whetstone, Qingxia Wei, and Benjamin A. Alman. “Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.” Nat Commun 6 (May 19, 2015): 7131. https://doi.org/10.1038/ncomms8131.
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Baht, Gurpreet S., David Silkstone, Puviindran Nadesan, Heather Whetstone, and Benjamin A. Alman. “Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.” J Orthop Res 32, no. 4 (April 2014): 581–86. https://doi.org/10.1002/jor.22562.
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Ng, Adeline, Gurpreet Baht, Marc Grynpas, and Benjamin Alman. “Osteoblast depletion increases osteoblast activity and reduces bone toughness in mice.” In Journal of Bone and Mineral Research, 29:S346–S346. WILEY-BLACKWELL, 2014.
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Craft, April M., Nazish Ahmed, Jason S. Rockel, Gurpreet S. Baht, Benjamin A. Alman, Rita A. Kandel, Agamemnon E. Grigoriadis, and Gordon M. Keller. “Specification of chondrocytes and cartilage tissues from embryonic stem cells.” Development 140, no. 12 (June 2013): 2597–2610. https://doi.org/10.1242/dev.087890.
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Ng, Adeline, Gurpreet Baht, Marc Grynpas, and Benjamin Alman. “Repeated Osteoblast Depletion Decreases Osteogenic Potential of Bone Marrow Stromal Cells in Mice.” In Journal of Bone and Mineral Research, Vol. 28. WILEY-BLACKWELL, 2013.
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Baht, Gurpreet, and Benjamin Alman. “Rejuvenating Bone Fracture Repair.” In Journal of Bone and Mineral Research, Vol. 28. WILEY-BLACKWELL, 2013.
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Baht, Gurpreet S., Jason O’Young, Antonia Borovina, Hong Chen, Coralee E. Tye, Mikko Karttunen, Gilles A. Lajoie, Graeme K. Hunter, and Harvey A. Goldberg. “Phosphorylation of Ser136 is critical for potent bone sialoprotein-mediated nucleation of hydroxyapatite crystals.” Biochem J 428, no. 3 (May 27, 2010): 385–95. https://doi.org/10.1042/BJ20091864.
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Goldberg, H. A., G. Baht, J. Gordon, V. Pitelka, H. Chen, D. Holdsworth, and G. K. Hunter. “Bone repair mediated by bone sialoprotein.” In European Cells and Materials, 16:47, 2008.
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Baht, G. S., G. K. Hunter, and H. A. Goldberg. “Bone sialoprotein-mediated mineral formation: Role of phosphorylation & development of a fusion peptide for bone repair.” In European Cells and Materials, 16:43, 2008.
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Baht, Gurpreet S., Graeme K. Hunter, and Harvey A. Goldberg. “Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation.” Matrix Biol 27, no. 7 (September 2008): 600–608. https://doi.org/10.1016/j.matbio.2008.06.004.
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Grants
- Modulation of local adenosine signaling to attenuate fracture pain (Co Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2021-2026 More info
- Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers (Co Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2021-2025 More info
- Assessing healthspan in aged mice after prolonged exposure to young circulation (Co Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2020-2023 More info
- Neurovascular dysfunction in delirium superimposed on dementia (Co Investigator), awarded by National Institutes of Health, administered by Anesthesiology, 2017-2023 More info
- Correction of Immune Response Improves Aged Fracture Healing (Principal Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2020-2022 More info
- Extracellular Vesicles and Their Role in Hallmarks of Aging (Collaborating Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2018-2020 More info
- Investigating the role of Apolipoprotein E in pseudarthrosis following spinal fusion surgery (Co Investigator), awarded by AOSpine International, administered by Neurosurgery, 2019-2020 More info
People
- Gurpreet Baht, PhD
- Xiaohua Zong
- Rong Huang, PhD
Contact
Duke Molecular Physiology Institute
Carmichael Building
300 North Duke Street
Room 51–208F
Durham, North Carolina 27701
Phone 919-681-2864
Fax 919-684-0903
gurpreet.baht@duke.edu