Assistant Professor
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2019
Education, Training, & Certifications
M.D., Tongji Medical College (China) 2001
Medical Instructor in the Department of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2019 - 2021
Selected Grants
Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers awarded by National Institutes of Health 2021 - 2025
Academic Articles
Chen, Yu-Hsiu, Xin Zhang, Kuei-Yueh Ko, Ming-Feng Hsueh, and Virginia Byers Kraus. “CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.” Oxid Med Cell Longev 2022 (2022): 5503575. https://doi.org/10.1155/2022/5503575.
Zhang, Xin, Janet L. Huebner, and Virginia Byers Kraus. “Extracellular Vesicles as Biological Indicators and Potential Sources of Autologous Therapeutics in Osteoarthritis.” Int J Mol Sci 22, no. 15 (August 3, 2021). https://doi.org/10.3390/ijms22158351.
Hsueh, Ming-Feng, Xin Zhang, Samuel S. Wellman, Michael P. Bolognesi, and Virginia B. Kraus. “Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression.” Arthritis Rheumatol 73, no. 1 (January 2021): 89–99. https://doi.org/10.1002/art.41486.
Zhang, Xin, Ming-Feng Hsueh, Janet L. Huebner, and Virginia B. Kraus. “TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression.” Front Immunol 12 (2021): 758386. https://doi.org/10.3389/fimmu.2021.758386.
Zhang, X., M. -. F. Hsueh, and V. B. Kraus. “Evaluation of CD34+ hematopoietic stem cell-associated extracellular vesicles as a potential personalized therapy for osteoarthritis.” Osteoarthritis and Cartilage 28 (April 2020): S331–32. https://doi.org/10.1016/j.joca.2020.02.512.
Zhang, Xin, Monica Jeanne Hubal, and Virginia Byers Kraus. “Immune cell extracellular vesicles and their mitochondrial content decline with ageing.” Immun Ageing 17 (2020): 1. https://doi.org/10.1186/s12979-019-0172-9.
Zhang, Xin, Nazanin Kiapour, Sahil Kapoor, Tabish Khan, Madhan Thamilarasan, Yazhong Tao, Stephanie Cohen, Ryan Miller, Raymond A. Sobel, and Silva Markovic-Plese. “IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.” J Immunol 203, no. 5 (September 1, 2019): 1142–50. https://doi.org/10.4049/jimmunol.1900311.
Zhang, Xin, Nazanin Kiapour, Sahil Kapoor, Joseph R. Merrill, Yongjuan Xia, Woomi Ban, Stephanie M. Cohen, et al. “IL-11 antagonist suppresses Th17 cell-mediated neuroinflammation and demyelination in a mouse model of relapsing-remitting multiple sclerosis.” Clin Immunol 197 (December 2018): 45–53. https://doi.org/10.1016/j.clim.2018.08.006.
Tao, Yazhong, Xin Zhang, and Silva Markovic-Plese. “Toll-like receptor (TLR)7 and TLR9 agonists enhance interferon (IFN) beta-1a's immunoregulatory effects on B cells in patients with relapsing-remitting multiple sclerosis (RRMS).” J Neuroimmunol 298 (September 15, 2016): 181–88. https://doi.org/10.1016/j.jneuroim.2016.07.019.
Tao, Yazhong, Xin Zhang, Robert Zivadinov, Michael G. Dwyer, Cheryl Kennedy, Niels Bergsland, Deepa Ramasamy, et al. “Immunologic and MRI markers of the therapeutic effect of IFN-β-1a in relapsing-remitting MS.” Neurol Neuroimmunol Neuroinflamm 2, no. 6 (December 2015): e176. https://doi.org/10.1212/NXI.0000000000000176.
Dwyer, Michael G., Robert Zivadinov, Yazhong Tao, Xin Zhang, Cheryl Kennedy, Niels Bergsland, Deepa P. Ramasamy, et al. “Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: an open-label two-arm trial.” Bmc Neurol 15 (November 11, 2015): 232. https://doi.org/10.1186/s12883-015-0488-9.
Zhang, Xin, Tracy Putoczki, and Silva Markovic-Plese. “IL-11 in multiple sclerosis.” Oncotarget 6, no. 32 (October 20, 2015): 32297–98. https://doi.org/10.18632/oncotarget.6027.
Zhang, Xin, Yazhong Tao, Manisha Chopra, Irena Dujmovic-Basuroski, Jianping Jin, Yunan Tang, Jelena Drulovic, and Silva Markovic-Plese. “IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.” J Immunol 194, no. 11 (June 1, 2015): 5139–49. https://doi.org/10.4049/jimmunol.1401680.
Blauth, Kevin, Xin Zhang, Manisha Chopra, Sarah Rogan, and Silva Markovic-Plese. “The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis.” Clin Immunol 157, no. 2 (April 2015): 121–32. https://doi.org/10.1016/j.clim.2015.01.001.
Tao, Yazhong, Xin Zhang, Manisha Chopra, Ming-Jeong Kim, Kinnari R. Buch, Dehan Kong, Jianping Jin, et al. “The role of endogenous IFN-β in the regulation of Th17 responses in patients with relapsing-remitting multiple sclerosis.” J Immunol 192, no. 12 (June 15, 2014): 5610–17. https://doi.org/10.4049/jimmunol.1302580.
Zhang, Xin, Yazhong Tao, Manisha Chopra, Mihye Ahn, Karen L. Marcus, Neelima Choudhary, Hongtu Zhu, and Silva Markovic-Plese. “Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis.” J Immunol 191, no. 12 (December 15, 2013): 5867–74. https://doi.org/10.4049/jimmunol.1301926.
Zhang, Xin, Yazhong Tao, Jinzhao Wang, Rafael Garcia-Mata, and Silva Markovic-Plese. “Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis.” Eur J Immunol 43, no. 1 (January 2013): 281–89. https://doi.org/10.1002/eji.201242566.
Broux, Bieke, Kim Pannemans, Xin Zhang, Silva Markovic-Plese, Tom Broekmans, Bert O. Eijnde, Bart Van Wijmeersch, et al. “CX(3)CR1 drives cytotoxic CD4(+)CD28(-) T cells into the brain of multiple sclerosis patients.” J Autoimmun 38, no. 1 (February 2012): 10–19. https://doi.org/10.1016/j.jaut.2011.11.006.
Zhang, Xin, Yazhong Tao, Luigi Troiani, and Silva Markovic-Plese. “Simvastatin inhibits IFN regulatory factor 4 expression and Th17 cell differentiation in CD4+ T cells derived from patients with multiple sclerosis.” J Immunol 187, no. 6 (September 15, 2011): 3431–37. https://doi.org/10.4049/jimmunol.1100580.
Zhang, Xin, and Silva Markovic-Plese. “Interferon beta inhibits the Th17 cell-mediated autoimmune response in patients with relapsing-remitting multiple sclerosis.” Clin Neurol Neurosurg 112, no. 7 (September 2010): 641–45. https://doi.org/10.1016/j.clineuro.2010.04.020.
Ramgolam, Vinod S., Yonggang Sha, Jianping Jin, Xin Zhang, and Silva Markovic-Plese. “IFN-beta inhibits human Th17 cell differentiation.” J Immunol 183, no. 8 (October 15, 2009): 5418–27. https://doi.org/10.4049/jimmunol.0803227.
Zhang, Xin, Jianping Jin, Yunan Tang, Danielle Speer, Danuta Sujkowska, and Silva Markovic-Plese. “IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation.” J Immunol 182, no. 6 (March 15, 2009): 3928–36. https://doi.org/10.4049/jimmunol.0802226.
Montes, Monica, Xin Zhang, Laureline Berthelot, David-Axel Laplaud, Sophie Brouard, Jianping Jin, Sarah Rogan, et al. “Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells.” Clin Immunol 130, no. 2 (February 2009): 133–44. https://doi.org/10.1016/j.clim.2008.08.030.
Zhang, Xin, Jianping Jin, Xueyan Peng, Vinod S. Ramgolam, and Silva Markovic-Plese. “Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.” J Immunol 180, no. 10 (May 15, 2008): 6988–96. https://doi.org/10.4049/jimmunol.180.10.6988.
Zhang, Xin, Yunan Tang, Danuta Sujkowska, Jinzhao Wang, Vinod Ramgolam, Mireia Sospedra, Jeremy Adams, Roland Martin, Clemencia Pinilla, and Silva Markovic-Plese. “Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis.” Eur J Immunol 38, no. 5 (May 2008): 1297–1309. https://doi.org/10.1002/eji.200737519.
Zhang, Xin, and Silva Markovic-Plese. “Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response.” Immunol Res 41, no. 3 (2008): 165–74. https://doi.org/10.1007/s12026-008-8019-z.
Kiapour, Nazanin, Bing Wu, Yan Wang, Maryamsadat Seyedsadr, Sahil Kapoor, Xin Zhang, Manal Elzoheiry, Ezgi Kasimoglu, Yisong Wan, and Silva Markovic-Plese. “Therapeutic Effect of Anti-CD52 Monoclonal Antibody in Multiple Sclerosis and Its Animal Models Is Mediated via T Regulatory Cells.” J Immunol 209, no. 1 (July 1, 2022): 49–56. https://doi.org/10.4049/jimmunol.2100176.
Zhang, Xin, Gurpreet Singh Baht, Rong Huang, Yu-Hsiu Chen, Kristin Happ Molitoris, Sara E. Miller, and Virginia Byers Kraus. “Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.” Aging Cell, June 3, 2022, e13651. https://doi.org/10.1111/acel.13651.
Chen, Y. -. H., X. Zhang, D. Attarian, and V. Kraus. “DPP4 - A POTENTIAL SENESCENT CHONDROCYTE BIOMARKER IN OSTEOARTHRITIS.” Osteoarthritis and Cartilage 30 (April 2022): S122–S122. https://doi.org/10.1016/j.joca.2022.02.156.
Montes, Monica, Xin Zhang, Laureline Berthelot, David-Axel Laplaud, Sophie Brouard, Jianping Jin, Sarah Rogan, et al. “Corrigendum to “Oligoclonal myelin-reactive T-cell infiltrates derived from neuromyelitis optica spectrum disorder (NMOSD) lesions are enriched in Th17 cells” [Clinical Immunology 130 (2009) 133–144].” Clinical Immunology 237 (April 2022): 108967–108967. https://doi.org/10.1016/j.clim.2022.108967.
Zhang, X., S. Ma, A. Reed, T. Ho, G. Waitt, E. J. Soderblom, C. Aliferis, and V. B. Kraus. “PROTEOMIC SIGNATURES OF EXTRACELLULAR VESICLES DERIVED FROM SYNOVIAL FLUID AND PLASMA OF PARTICIPANTS WITH KNEE OSTEOARTHRITIS.” Osteoarthritis and Cartilage 30 (April 2022): S121–S121. https://doi.org/10.1016/j.joca.2022.02.154.