Professor of Medicine
Professor of Pathology
Professor in Orthopaedic Surgery
Member of Duke Molecular Physiology Institute
Affiliate of the Regeneration Next Initiative
My special area of expertise is as a clinician-scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in humans and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.
The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation, and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, predicting progression of the disease, and monitoring disease progression and response to therapy.
Selected Publications and Grants
Publications
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Goode, Adam P., David Hu, Steven Z. George, Todd A. Schwartz, Virginia B. Kraus, Janet L. Huebner, Rebecca J. Cleveland, Kenneth A. Taylor, Joanne M. Jordan, and Yvonne M. Golightly. “Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: The Johnston County Osteoarthritis Project (Accepted).” Osteoarthritis and Cartilage Open 4, no. 3 (September 2022): 100270–100270. https://doi.org/10.1016/j.ocarto.2022.100270.
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Alexander, Louie C., Janet L. Huebner, Greg Cicconetti, Joanne M. Jordan, Jordan B. Renner, Michael Doherty, Anthony G. Wilson, Marc C. Hochberg, Richard Loeser, and Virginia Byers Kraus. “Tibiofemoral knee osteoarthritis progresses symmetrically by knee compartment in the GOGO cohort (Accepted).” Osteoarthritis and Cartilage Open 4, no. 3 (September 2022): 100288–100288. https://doi.org/10.1016/j.ocarto.2022.100288.
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Hunter, David J., Leticia A. Deveza, Jamie E. Collins, Elena Losina, Jeffrey N. Katz, Michael C. Nevitt, John A. Lynch, et al. “Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.” Arthritis Care Res (Hoboken) 74, no. 7 (July 2022): 1142–53. https://doi.org/10.1002/acr.24557.
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Zhang, Xin, Gurpreet Singh Baht, Rong Huang, Yu-Hsiu Chen, Kristin Happ Molitoris, Sara E. Miller, and Virginia Byers Kraus. “Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.” Aging Cell, June 3, 2022, e13651. https://doi.org/10.1111/acel.13651.
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Orenduff, Melissa C., Michael F. Coleman, Elaine M. Glenny, Kim M. Huffman, Erika T. Rezeli, Akshay Bareja, Carl F. Pieper, Virginia B. Kraus, and Stephen D. Hursting. “Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.” Exp Gerontol, May 24, 2022, 111841. https://doi.org/10.1016/j.exger.2022.111841.
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Lv, Y., C. Mao, X. Gao, J. S. Ji, V. B. Kraus, Z. Yin, J. Yuan, et al. “The obesity paradox is mostly driven by decreased noncardiovascular disease mortality in the oldest old in China: a 20-year prospective cohort study.” Nature Aging 2, no. 5 (May 1, 2022): 389–96. https://doi.org/10.1038/s43587-022-00201-3.
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Cen, Han, Qingran Yan, Weiyu Han, Tao Meng, Zhongshan Chen, Guangfeng Ruan, Tian Wang, et al. “Longitudinal Association of Infrapatellar Fat Pad Signal Intensity Alteration with Biochemical Biomarkers in Knee Osteoarthritis.” Rheumatology (Oxford), April 6, 2022. https://doi.org/10.1093/rheumatology/keac214.
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Hsueh, M. -. F., A. Reed, M. Orenduff, M. P. Bolognesi, M. E. Easley, P. Onnerfjord, and V. B. Kraus. “CARTILAGE ANABOLISM IS HIGHLY REGULATED BY MIRNAS IN RESPONSE TO OA STRESS.” In Osteoarthritis and Cartilage, 30:S356–57, 2022.
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Zhang, X., S. Ma, A. Reed, T. Ho, G. Waitt, E. J. Soderblom, C. Aliferis, and V. B. Kraus. “PROTEOMIC SIGNATURES OF EXTRACELLULAR VESICLES DERIVED FROM SYNOVIAL FLUID AND PLASMA OF PARTICIPANTS WITH KNEE OSTEOARTHRITIS.” Osteoarthritis and Cartilage 30 (April 2022): S121–S121. https://doi.org/10.1016/j.joca.2022.02.154.
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Reed, A., M. -. F. Hsueh, J. L. Huebner, Y. -. J. Li, B. Ma, A. Krych, S. Rodeo, S. Majumdar, and V. B. Kraus. “SURGERY INDUCES SECOND CYTOKINE STORM IN INDIVIDUALS WHO EXPERIENCE AN ANTERIOR CRUCIATE LIGAMENT TEAR.” In Osteoarthritis and Cartilage, 30:S100–101, 2022.
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Grants
- University Training Program in Biomolecular and Tissue Engineering (Mentor), awarded by National Institutes of Health, administered by Biomedical Engineering, 1994-2027 More info
- Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers (Principal Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2021-2025 More info
- Behavior and Physiology in Aging (Mentor), awarded by National Institutes of Health, administered by Center for the Study of Aging and Human Development, 2015-2025 More info
- Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic Health (Co Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2021-2025 More info
- Mechanical Biomarkers of Chronic Low Back Pain (Co Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
- Weight loss, in vivo cartilage mechanics, and joint health (Co Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2023 More info
- Exercise Induced Muscle Secreted Factors That Modify Osteoarthritis (OA) Severity (Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2021-2023 More info
- Epigenetic Mechanisms Promoting Longevity (Principal Investigator), awarded by National Institutes of Health, administered by Duke Molecular Physiology Institute, 2018-2023 More info
- Development of an Early Osteoarthritis Diagnostic Panel via a Proteomic Approach (Principal Investigator), awarded by Zimmer Biomet Company, administered by Duke Molecular Physiology Institute, 2018-2022 More info
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) (Investigator), awarded by National Institutes of Health, administered by Center for the Study of Aging and Human Development, 2017-2022 More info
Contact
300 N. Duke Street
Carmichael Building Room 15-205, Durham, NC 27701
Duke Box 104775, Durham, NC 27701
919-681-6652
vbk@duke.edu