We study osteosarcoma in a unique capacity:

• Our focus is the field of Comparative Oncology - the study of cancer across different species.
   
• The overall hypothesis is that by understanding the standard drivers of specific cancer types from one species to another, we can learn "what really matters" about that type of cancer.
   
• We also have a variety of clinical and translational research opportunities.

Grants

• SCH: Overcoming the Intraoperative Data Desert: Biophotonics, Advanced Sensing, and Control for Automated Surgery ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2024
   
• Phase 1 Study of X-PACT (X-ray Psoralen Activated Cancer Therapy) Clinical TrialPrincipal Investigator · Awarded by Immunolight, LLC · 2021 - 2024
   
• Modeling tumor heterogeneity and therapy resistance in osteosarcoma using patient-derived organoids ResearchCo Investigator · Awarded by Hyundai Hope on Wheels · 2021 - 2023
   
• Development and validation of anti-canine reagents to enable pre-clinical development of novel therapeuticsResearchPrincipal Investigator · Awarded by AvantGen, Inc. · 2020 - 2023
   
• Investigating the abscopal effect of Immunolight in murine models of melanoma and soft tissue sarcoma in vivo. ResearchPrincipal Investigator · Awarded by Immunolight, LLC · 2021 - 2023

Selected Publications

• Mesfin, Addisu, Sasha Carsen, Jonathan F. Dickens, William Eward, Anna N. Miller, Themistocles Protopsaltis, and Michael J. Monument. “The 2022 American-British-Canadian (ABC) Traveling Fellowship: The Post-Pandemic Tour.” J Bone Joint Surg Am, August 23, 2023. https://doi.org/10.2106/JBJS.23.00538.

• Ray, G. S., P. Werth, J. H. Alexander, W. C. Eward, N. M. Bernthal, L. M. Jeys, P. Funovics, et al. “Surgical Site Infection in Patients Managed with an Endoprosthesis for the Treatment of Cancer: Evaluation of Patient, Disease, and Index Surgical Factors.” J Bone Joint Surg Am 105, no. Suppl 1 (July 19, 2023): 87–96. https://doi.org/10.2106/JBJS.22.01376.

• Floyd, Warren, Matthew Pierpoint, Chang Su, Rutulkumar Patel, Lixia Luo, Katherine Deland, Amy J. Wisdom, et al. “Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus.” The Journal of Clinical Investigation 133, no. 13 (July 2023): e149310. https://doi.org/10.1172/jci149310.

• Lazarides, Alexander L., Bijan Abar, Bruce Leckey, John T. Martin, Evelyna G. Kliassov, Brian E. Brigman, William C. Eward, Diana M. Cardona, and Julia D. Visgauss. “Tumor necrosis is an underappreciated histopathologic factor in the grading of chondrosarcoma.” Bmc Cancer 23, no. 1 (June 23, 2023): 579. https://doi.org/10.1186/s12885-023-11022-x.

• Bray, Jonathan, Will Eward, and Matthew Breen. “Defining the relevance of surgical margins. Part two: Strategies to improve prediction of recurrence risk.” Vet Comp Oncol 21, no. 2 (June 2023): 145–58. https://doi.org/10.1111/vco.12881.

• Abar, Bijan, Junheng Gao, Amanda N. Fletcher, Elizbeth Sachs, Andrew H. Wong, Alexander L. Lazarides, Chinedu Okafor, et al. “Regional anesthesia is associated with improved metastasis free survival after surgical resection of bone sarcomas.” J Orthop Res, May 8, 2023. https://doi.org/10.1002/jor.25597.

• Tabarestani, Troy Q., Nicole Levine, Elizabeth Sachs, Ashley Scholl, Roy Colglazier, Robert French, Rami Al-Rohil, Brian Brigman, William Eward, and Julia Visgauss. “Giant cell tumor of bone in the pediatric population: a retrospective study highlighting cases of metaphyseal only location and increased local recurrence rates in skeletally immature patients.” Skeletal Radiol, May 8, 2023. https://doi.org/10.1007/s00256-023-04359-8.

• Sag, Alan A., Richard F. Riedel, William C. Eward, Julia D. Visgauss, and Brian E. Brigman. “Hydropneumodissection-Assisted Cryoablation of Recurrent Sarcoma Adjacent to the Sciatic Nerve as a Limb-Sparing Alternative to Hindquarter Amputation.” J Vasc Interv Radiol 34, no. 5 (May 2023): 923-926.e1. https://doi.org/10.1016/j.jvir.2022.12.469.

• Bray, Jonathan, Will Eward, and Matthew Breen. “Evaluating the relevance of surgical margins. Part one: The problems with current methodology.” Vet Comp Oncol 21, no. 1 (March 2023): 1–11. https://doi.org/10.1111/vco.12865.

• Karasik, R., N. E. Lauer, A. E. Baker, N. E. Lisi, J. A. Somarelli, W. C. Eward, K. Fürst, and M. M. Dunphy-Daly. “Inequitable distribution of plastic benefits and burdens on economies and public health.” Frontiers in Marine Science 9 (January 10, 2023). https://doi.org/10.3389/fmars.2022.1017247.

• Karasik, R., N. E. Lauer, A. E. Baker, N. E. Lisi, J. A. Somarelli, W. C. Eward, K. Fürst, and M. M. Dunphy-Daly. “Inequitable distribution of plastic benefits and burdens on economies and public health.” Frontiers in Marine Science 9 (January 10, 2023). https://doi.org/10.3389/fmars.2022.1017247.

• Foreman, Jordan, Kevin Krughoff, William Eward, Edward Hendershot, Christopher Mantyh, and Andrew Peterson. “SEVERE POST-OPERATIVE COMPLICATIONS ARE RARE IN PATIENTS WITH URINARY-PUBIC SYMPHYSIS FISTULAE AND PUBIC BONE OSTEOMYELITIS (UPF-OM) UNDERGOING EXTIRPATIVE SURGERY; DATA FROM THE NATIONAL SURGICAL QUALITY IMPROVEMENT PROGRAM.” In Journal of Urology, 209:E467–E467, 2023.

• Sag, Alan A., William A. L. Sperduto, William Eward, James Ronald, Haley Davis, Xiaoyin Sara Jiang, David S. Enterline, et al. “Juxtametallic Bipolar Bone Radiofrequency Ablation: Thermal Monitoring in an Ex-Vivo Model with Specimen MRI and Histopathologic Correlation.” J Vasc Interv Radiol 33, no. 12 (December 2022): 1594–1600. https://doi.org/10.1016/j.jvir.2022.08.019.

• Diana, Z., R. Karasik, G. B. Merrill, M. Morrison, K. A. Corcoran, D. Vermeer, E. Hepler-Smith, et al. “A transdisciplinary approach to reducing global plastic pollution.” Frontiers in Marine Science 9 (October 28, 2022). https://doi.org/10.3389/fmars.2022.1032381.

• Byers, Isabelle S., Nicholas A. Turner, Nicole L. Levine, Alexander L. Lazarides, Daniel R. Evans, Ivan Spasojevic, Ping Fan, et al. “Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration.” Antimicrob Agents Chemother 66, no. 10 (October 18, 2022): e0014022. https://doi.org/10.1128/aac.00140-22.

• Lazarides, Alexander L., Eliana B. Saltzman, Julia D. Visgauss, Suhail K. Mithani, William C. Eward, and Brian E. Brigman. “Intraoperative angiography imaging correlates with wound complications following soft tissue sarcoma resection.” J Orthop Res 40, no. 10 (October 2022): 2382–90. https://doi.org/10.1002/jor.25270.

• Bartholf DeWitt, Suzanne, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E. J. Martz, Maryam Zand, Vardhman Kumar, et al. “Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.” Jci Insight 7, no. 17 (September 8, 2022). https://doi.org/10.1172/jci.insight.151583.

• Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Niall Cochrane, Junheng Gao, Sin-Ho Jung, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone.” J Surg Oncol 126, no. 2 (August 2022): 356–64. https://doi.org/10.1002/jso.26864.

• Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Corrigendum to 'Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?' [The Journal of Arthroplasty 37 (2022) 232-237].” J Arthroplasty 37, no. 6 (June 2022): 1212. https://doi.org/10.1016/j.arth.2022.01.041.

• Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1392–1408. https://doi.org/10.1245/s10434-021-10802-8.

If you would like to join the team, contact Dr. Eward. 

Hyundai Hope on Wheels

National Hyundai Hope on Wheels · 2017 We are excited to announce that Will Eward, MD, DVM, has received the Hyundai Hope on Wheels $250,000 award! Hyundai Hope On Wheels creates awareness for pediatric cancers and awards large grants to doctors and premiere research centers for life-saving research. This 19-year HHOW commitment awards grants to researchers at eligible Children’s Oncology Group member institutions in various categories. The highly competitive grants aim to expand the knowledge base of the disease and improve the standards of care. As an Orthopaedic Oncologist, Dr. Eward specializes in preserving and reconstructing limbs that have been jeopardized by a type of cancer called Sarcoma. Given his dual roles in human and animal health, Dr. Eward is committed to using a One Medicine approach to solving the terrible problem that cancer presents to all of us, whether we walk on two legs or four. His research attempts to identify common elements between types of cancer across different species. You can read more about Dr. Eward's research efforts at: • https://sites.duke.edu/dukecancerinstitute/the-answer-on-the-other-end-o... • http://www.cancer.duke.edu/comparativeoncology/ • https://sites.duke.edu/dukecancerinstitute/enlisting-a-dog-in-the-fight-... • https://sites.duke.edu/dukecancerinstitute/researchers-identify-genes-th... • http://people.com/pets/veterinarian-goes-back-to-medical-school-to-help-...More about this award

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