Vice Chair Biomechanics, Movement, and Imaging Research Department of Orthopaedic Surgery
Professor in the Department of Mechanical Engineering and Material Science
Associate Professor in the Department of Biomedical Engineering
Affiliate of the Regeneration Next Initiative
Lab Site: sites.duke.edu/defratelab/
The DeFrate laboratory applies engineering principles to study clinically-relevant problems involving the musculoskeletal system. In particular, they evaluate in vivo biomechanics using advanced radiographic and MRI techniques, which enables them to investigate soft tissue structure, composition, and function in healthy and diseased states.
Selected Publications and Grants
Publications
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Heckelman, L. N., Soher, B. J., Spritzer, C. E., Lewis, B. D., & DeFrate, L. E. (2022). Design and validation of a semi-automatic bone segmentation algorithm from MRI to improve research efficiency. Sci Rep, 12(1), 7825. https://doi.org/10.1038/s41598-022-11785-6
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Martin, J. T., Oldweiler, A. B., Kosinski, A. S., Spritzer, C. E., Soher, B. J., Erickson, M. M., … DeFrate, L. E. (2022). Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region. Eur Spine J, 31(3), 746–754. https://doi.org/10.1007/s00586-021-07097-4
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Tamayo, K. S., Heckelman, L. N., Spritzer, C. E., DeFrate, L. E., & Collins, A. T. (2022). Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation. J Biomech, 134, 110991. https://doi.org/10.1016/j.jbiomech.2022.110991
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Martin, J. T., Wesorick, B., Oldweiler, A. B., Kosinski, A. S., Goode, A. P., & DeFrate, L. E. (2022). In vivo fluid transport in human intervertebral discs varies by spinal level and disc region. Jor Spine. https://doi.org/10.1002/jsp2.1199
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Cutcliffe, H. C., Kottamasu, P. K., McNulty, A. L., Goode, A. P., Spritzer, C. E., & DeFrate, L. E. (2021). Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping. J Biomech, 129, 110771. https://doi.org/10.1016/j.jbiomech.2021.110771
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Heckelman, L. N., Wesorick, B. R., DeFrate, L. E., & Lee, R. H. (2021). Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans. J Biomech, 128, 110707. https://doi.org/10.1016/j.jbiomech.2021.110707
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Kim-Wang, S. Y., Holt, A. G., McGowan, A. M., Danyluk, S. T., Goode, A. P., Lau, B. C., … McNulty, A. L. (2021). Immune cell profiles in synovial fluid after anterior cruciate ligament and meniscus injuries. Arthritis Res Ther, 23(1), 280. https://doi.org/10.1186/s13075-021-02661-1
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Andress, B., Kim, J. H., Cutcliffe, H. C., Amendola, A., Goode, A. P., Varghese, S., … McNulty, A. L. (2021). Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding. J Orthop Res, 39(10), 2177–2186. https://doi.org/10.1002/jor.24954
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Coppock, J. A., Danyluk, S. T., Englander, Z. A., Spritzer, C. E., Goode, A. P., & DeFrate, L. E. (2021). Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test. J Biomech, 121, 110392. https://doi.org/10.1016/j.jbiomech.2021.110392
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Englander, Z. A., Lau, B. C., Wittstein, J. R., Goode, A. P., & DeFrate, L. E. (2021). Patellar Tendon Orientation and Strain Are Predictors of ACL Strain In Vivo During a Single-Leg Jump. Orthop J Sports Med, 9(3), 2325967121991054. https://doi.org/10.1177/2325967121991054
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Grants
- Mentoring in Musculoskeletal Pain Phenotypes (Collaborator), awarded by National Institutes of Health, administered by Orthopaedics, Physical Therapy, 2022-2027 More info
- Biomechanical and Biological Predictors of Cartilage Health Following Meniscus Injury (Co-Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2021-2026 More info
- In Vivo Knee Motion and ACL Biomechanics During Dynamic Activities (Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
- Mechanical Biomarkers of Chronic Low Back Pain (Co-Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2024 More info
- Weight loss, in vivo cartilage mechanics, and joint health (Principal Investigator), awarded by National Institutes of Health, administered by Orthopaedics, 2019-2023 More info
- Quantitative MRI of Glenohumeral Cartilage & Labrum in Shoulder Instability (Co-Principal Investigator), awarded by Orthopaedic Research and Education Foundation, administered by Orthopaedics, 2022-2023 More info
- Duke CTSA (TL1) Year 5 (Mentor), awarded by National Institutes of Health, administered by Institutes and Centers, 2018-2023 More info
- Metabolomic & Radiographic Markers of Fracture Risk Among Older Adults with Diabetes (K23) (Co-Mentor), awarded by National Institutes of Health, administered by Medicine, Endocrinology, Metabolism, and Nutrition, 2018-2023 More info
- Development of Chondroregenerative Therapy for Human Osteoarthritis (Principal Investigator), awarded by University of Rochester Medical Center, administered by Orthopaedics, 2017-2022 More info
- Exercise-induced recovery of intervertebral disc health (Collaborator), awarded by National Institutes of Health, administered by Orthopaedics, 2020-2022 More info
Contact
Medical Sciences Research Building I, 203 Research Drive, Room 379
DUMC Box 3093, Durham, NC 27710
919-681-9959
lou.defrate@duke.edu