Louis E. DeFrate, ScD

Lou DeFrate
Vice Chair Biomechanics, Movement, and Imaging Research; Professor of Orthopaedic Surgery

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Dr. DeFrate is the Vice Chair Biomechanics, Movement, and Imaging Research and a Professor of Orthopaedic Surgery. He holds appointments in the Department of Mechanical Engineering and Materials Science and the Department of Biomedical Engineering. Dr. DeFrate is also the current director of the K-lab. Dr. DeFrate’s research focuses on the application of engineering principles to investigate clinically relevant problems related to the musculoskeletal system, with a particular interest in biomechanics and advanced radiographic and MR imaging. Dr. DeFrate is currently the principal investigator of three NIH R01 grants related to the biomechanics of the knee and spine. Dr. DeFrate’s lab is in Medical Science Research Building (MRSB) 1.

Publications from the 2020-2021 Academic Year

 ·Cutcliffe HC, DeFrate LE. Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery. Sci Rep. 2020 Jan 31;10(1):1547.

·Englander  ZA, Garrett WE, Spritzer CE, DeFrate LE. In vivo attachment site to attachment site length and strain of the ACL and its bundles during the full gait cycle measured by MRI and high-speed biplanar radiography. J Biomech. 2020 Jan 2;98:109443

·Heckelman LN, Smith WAR, Riofrio AD, Vinson EN, Collins AT, Gwynn OR, Utturkar GM, Goode AP, Spritzer CE, DeFrate LE. Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging. Sci Rep. 2020 Feb 5;10(1):1870.

·Goode AP, Schwartz TA, Kraus VB, Huebner JL, George SZ, Cleveland RJ, Gracely R, Jimenez M, DeFrate LE, Chen J, Golightly YM, Jordan JM. Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project. J Orthop Res. 2020 May;38(5):1027-1037

·Englander ZA, Wittstein JR, Goode AP, Garrett WE, DeFrate LE. Reconsidering Reciprocal Length Patterns of the Anteromedial and Posterolateral Bundles of the Anterior Cruciate Ligament During In Vivo Gait. Am J Sports Med. 2020 Jul;48(8):1893-1899.

·Cutcliffe HC, Davis KM, Spritzer CE, DeFrate L. The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical FunctionAnn Biomed Eng. 2020 Jul 14.

·Andress B, Kim JH, Cutcliffe HC, Amendola A, Goode AP, Varghese S, DeFrate LE, McNulty AL. Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding. J Orthop Res. 2020 Dec 15.

·Collins AT, Hu G, Newman H, Reinsvold MH, Goldsmith MR, Twomey-Kozak JN, Leddy HA, Sharma D, Shen L, DeFrate LE, Karner CM. Obesity alters the collagen organization and mechanical properties of murine cartilage. Sci Rep. 2021 Jan 15;11(1):1626.

·Collins AT, Kulvaranon M, Spritzer CE, McNulty AL, DeFrate LE. The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain. Orthop J Sports Med. 2020 Dec 3;8(12):2325967120964468. 

·Crook BS, Collins AT, Lad NK, Spritzer CE, Wittstein JR, DeFrate LE. Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees. J Biomech. 2020 Dec 28;116:110210.

·Heckelman LN, Riofrio AD, Vinson EN, Collins AT, Gwynn OR, Utturkar GM, Goode AP, Spritzer CE, DeFrate LE. Dose and Recovery Response of Patellofemoral Cartilage Deformations to Running. Orthop J Sports Med. 2020 Dec 9;8(12):2325967120967512.

·Kim-Wang SY, Scribani MB, Whiteside MB, DeFrate LE, Lassiter TE, Wittstein JR. Distribution of Bone Contusion Patterns in Acute Noncontact Anterior Cruciate Ligament-Torn Knees. Am J Sports Med. 2021 Jan 7:363546520981569

·Coppock JA, Danyluk ST, Englander ZA, Spritzer CE, Goode AP, DeFrate LE. Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test. J Biomech. 2021 Mar 20;121:110392.

·Englander ZA, Lau BC, Wittstein JR, Goode AP, DeFrate LE. Patellar Tendon Orientation and Strain Are Predictors of ACL Strain In Vivo During a Single-Leg Jump. Orthop J Sports Med. 2021 Mar 18;9(3):2325967121991054.

·Goode AP, Cleveland RJ, George SZ, Schwartz TA, Kraus VB, Renner JB, Gracely RH, DeFrate LE, Hu D, Jordan JM, Golightly YM. Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken). 2021 May 10. doi: 10.1002/acr.24643..

·Cutcliffe HC, Kottamasu PK, McNulty AL, Goode AP, Spritzer CE, DeFrate LE. Mechanical metrics may show improved ability to predict osteoarthritis compared to T1rho mapping. J Biomech. 2021 Sep 27;129:110771.