Dr. Adams’s research focuses on post-traumatic ankle arthritis, in particular assessing the metabolite differences in ankle arthritis and searching for new metabolite biomarkers of arthritis and the metabolic association between arthritis and depression.
In 2017 and 2015, Dr. Adams received the J. Leonard Goldner Award from the American Orthopaedic Foot & Ankle Society for the best basic science paper.
In 2019, Dr. Adams was awarded the top poster at the American Orthopaedic Association's (AOA) 132nd Annual Meeting.
In 2020, Dr. Adams received the Frank H. Bassett, III, MD Teaching Award from the Department of Orthopaedic Surgery at Duke.
Current Projects
- Common link of tryptophan metabolism in osteoarthritis and depression
- 3D bioprinting of cartilage and bone
- Development of post-traumatic arthritis
Selected Publications & Grants
Publications
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Allen, N. B., B. Abar, L. Johnson, J. Burbano, R. M. Danilkowicz, and S. B. Adams. “3D-bioprinted GelMA-gelatin-hydroxyapatite osteoblast-laden composite hydrogels for bone tissue engineering.” Bioprinting 26 (June 1, 2022). https://doi.org/10.1016/j.bprint.2022.e00196.
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Abar, Bijan, Nicholas Kwon, Nicholas B. Allen, Trent Lau, Lindsey G. Johnson, Ken Gall, and Samuel B. Adams. “Outcomes of Surgical Reconstruction Using Custom 3D-Printed Porous Titanium Implants for Critical-Sized Bone Defects of the Foot and Ankle.” Foot Ankle Int 43, no. 6 (June 2022): 750–61. https://doi.org/10.1177/10711007221077113.
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Cunningham, Daniel J., Ariana Paniagua, Isabel DeLaura, Gloria Zhang, Billy Kim, Jonathan Kim, Terry Lee, Micaela LaRose, Samuel Adams, and Mark J. Gage. “Regional Anesthesia Decreases Inpatient But Not Outpatient Opioid Demand in Ankle and Distal Tibia Fracture Surgery.” Foot Ankle Spec, April 19, 2022, 19386400221088452. https://doi.org/10.1177/19386400221088453.
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Allen, Nicholas B., Bijan Abar, Richard M. Danilkowicz, Virginia B. Kraus, Steven A. Olson, and Samuel B. Adams. “Intra-Articular Synovial Fluid With Hematoma After Ankle Fracture Promotes Cartilage Damage In Vitro Partially Attenuated by Anti-Inflammatory Agents.” Foot Ankle Int 43, no. 3 (March 2022): 426–38. https://doi.org/10.1177/10711007211046952.
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Chaudhary, Usamah N., Cambre N. Kelly, Benjamin R. Wesorick, Cameron M. Reese, Ken Gall, Samuel B. Adams, Guillermo Sapiro, and J Matias Di Martino. “Computational and image processing methods for analysis and automation of anatomical alignment and joint spacing in reconstructive surgery.” Int J Comput Assist Radiol Surg 17, no. 3 (March 2022): 541–51. https://doi.org/10.1007/s11548-021-02548-1.
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Kwon, Nicholas F., Richard M. Danilkowicz, Jaewhan Kim, Nathan L. Grimm, and Samuel B. Adams. “Short-Term Complications Following Total Ankle Arthroplasty and Associated Risk Factors: A NSQIP Database Analysis.” Foot Ankle Spec, February 1, 2022, 19386400211072380. https://doi.org/10.1177/19386400211072379.
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Cunningham, Daniel J., Michael Blatter, Samuel B. Adams, and Mark J. Gage. “State regulation positively impacts opioid prescribing patterns in ankle fracture surgery: A national and state-level analysis.” Injury 53, no. 2 (February 2022): 445–52. https://doi.org/10.1016/j.injury.2021.11.039.
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Cunningham, D. J., C. Wixted, N. B. Allen, A. Hanselman, and S. B. Adams. “How Has Opioid Prescribing in Total Ankle Arthroplasty Changed with Time and State Legislation? A National and State-Level Analysis.” Foot and Ankle Orthopaedics 7, no. 1 (January 1, 2022). https://doi.org/10.1177/2473011421S00159.
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Fletcher, A. N., N. Kwon, R. Danilkowicz, J. Kim, N. L. Grimm, and S. B. Adams. “Short Term Complications Following Total Ankle Arthroplasty and Associated Risk Factors: A NSQIP Database Analysis.” Foot and Ankle Orthopaedics 7, no. 1 (January 1, 2022). https://doi.org/10.1177/2473011421S00021.
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Danilkowicz, Richard M., Nathan L. Grimm, Jaewhan Kim, Jeffrey A. O’Donnell, Nicholas B. Allen, and Samuel B. Adams. “Increasing age and modifiable comorbidities are associated with short-term complications after open reduction and internal fixation of ankle fractures.” Eur J Orthop Surg Traumatol 32, no. 1 (January 2022): 113–19. https://doi.org/10.1007/s00590-021-02927-z.
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Grants
- Clinical Evaluation of the Integra Cadence Total Ankle System in Primary Ankle Joint Replacement (Principal Investigator), awarded by Integra LifeSciences, administered by Orthopaedics, 2017-2027 More info
- Exactech Vantage Total Ankle System (Principal Investigator), awarded by Exactech, Inc, administered by Orthopaedics, 2016-2026 More info
- 3D Printing Osteochondral Scaffolds for Critical Glenoid and Humeral Bone Defects (Co-Principal Investigator), awarded by Piedmont Orthopedic Foundation, administered by Orthopaedics, 2022-2022 More info
- Histology and biomechanical strength of osteochondral lesions of the talus following microfracture (Principal Investigator), awarded by Piedmont Orthopedic Foundation, administered by Orthopaedics, 2022-2022 More info
- From Bedside to Bench and Back: Developing the Future of 3D Bioprinted Musculoskeletal Tissues at Duke (Principal Investigator), awarded by Piedmont Orthopedic Foundation, administered by Orthopaedics, 2021-2022 More info
- Fresh Tissue Lab Agreement (Principal Investigator), awarded by Exactech, Inc, administered by Orthopaedics, 2022-2022 More info
- Fresh Tissue Lab Agreement (Principal Investigator), awarded by SouthTech Orthopedics, Inc., administered by Orthopaedics, 2022-2022 More info
- Does the Synovial Fluid Fracture Hematoma after Intra-articular Ankle Fracture Cause Cartilage Damage? (Principal Investigator), awarded by American Orthopaedic Foot & Ankle Society, administered by Orthopaedics, 2021-2022 More info
- Cadence Total Ankle Anthroplasty Retrospective Study (Principal Investigator), awarded by Integra LifeSciences, administered by Orthopaedics, 2020-2022 More info
- Fresh Tissue Lab Agreement (Principal Investigator), awarded by Zimmer, Inc., administered by Orthopaedics, 2022-2022 More info
People
- Samuel B. Adams, MD, Principal Investigator
- Terese Camp, Lab Manager
- Hidetoshi Tsushima, MD, PhD, Postdoctoral Research Scientist
Contact
DUMC 2887, Durham, NC 27710
919-660-5010
samuel.adams@duke.edu