Associate Professor in Orthopaedic Surgery
Dr. Eward is an orthopaedic oncologist, with dual clinical degrees (MD and DVM). He treats complex sarcomas in people and animals. His laboratory studies comparative oncology - discoveries we can make about cancer by analyses across different species.
Selected Publications and Grants
Publications
-
Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Corrigendum to 'Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?' [The Journal of Arthroplasty 37 (2022) 232-237].” J Arthroplasty 37, no. 6 (June 2022): 1212. https://doi.org/10.1016/j.arth.2022.01.041.
More info -
Lazarides, Alexander L., Etienne M. Flamant, Mark M. Cullen, Harrison R. Ferlauto, Niall Cochrane, Junheng Gao, Sin-Ho Jung, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone.” J Surg Oncol, March 23, 2022. https://doi.org/10.1002/jso.26864.
More info -
Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1392–1408. https://doi.org/10.1245/s10434-021-10802-8.
More info -
Lazarides, Alexander L., Jason A. Somarelli, Brian E. Brigman, Julia D. Visgauss, and William C. Eward. “ASO Author Reflections: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma.” Ann Surg Oncol 29, no. 2 (February 2022): 1409–10. https://doi.org/10.1245/s10434-021-10904-3.
More info -
Lazarides, Alexander L., Etienne M. Flamant, Mark C. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, and William C. Eward. “Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?” J Arthroplasty 37, no. 2 (February 2022): 232–37. https://doi.org/10.1016/j.arth.2021.10.019.
More info -
Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Jason A. Somarelli, Dan G. Blazer, Julia D. Visguass, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study.” Ann Surg Oncol 29, no. 2 (February 2022): 1411–12. https://doi.org/10.1245/s10434-021-10892-4.
More info -
Lazarides, Alexander L., Eliana B. Saltzman, Julia D. Visgauss, Suhail K. Mithani, William C. Eward, and Brian E. Brigman. “Intraoperative angiography imaging correlates with wound complications following soft tissue sarcoma resection.” J Orthop Res, January 10, 2022. https://doi.org/10.1002/jor.25270.
More info -
Rao, Sneha R., Alexander L. Lazarides, Bruce L. Leckey, Whitney O. Lane, Julia D. Visgauss, Jason A. Somarelli, David G. Kirsch, et al. “Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.” Cancer Med 11, no. 1 (January 2022): 194–206. https://doi.org/10.1002/cam4.4428.
More info -
Evans, Daniel R., Alexander L. Lazarides, Mark M. Cullen, Julia Dawn Visgauss, Jason A. Somarelli, Dan Blazer, Brian E. Brigman, and William C. Eward. “ASO Visual Abstract: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma-A National Cancer Database Study.” Ann Surg Oncol 28, no. Suppl 3 (December 2021): 449–50. https://doi.org/10.1245/s10434-021-10131-w.
More info -
Gilpin, Anna, Yuze Zeng, Jiaul Hoque, Ji Hyun Ryu, Yong Yang, Stefan Zauscher, William Eward, and Shyni Varghese. “Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.” Adv Healthc Mater 10, no. 23 (December 2021): e2100777. https://doi.org/10.1002/adhm.202100777.
More info
Grants
- SCH: Overcoming the Intraoperative Data Desert: Biophotonics, Advanced Sensing, and Control for Automated Surgery (Co-Investigator), awarded by National Institutes of Health, administered by Neurosurgery, 2020-2024 More info
- Phase 1 Study of X-PACT (X-ray Psoralen Activated Cancer Therapy) (Principal Investigator), awarded by Immunolight, LLC, administered by Orthopaedics, 2021-2024 More info
- Modeling tumor heterogeneity and therapy resistance in osteosarcoma using patient-derived organoids (Co Investigator), awarded by Hyundai Hope on Wheels, administered by Pediatrics, Hematology-Oncology, 2021-2023 More info
- Development of an Agent-Based Statistical Model to Estimate the Economic Impact of Perioperative Orthopaedic Surgery Complication in the United States (Principal Investigator), awarded by Piedmont Orthopedic Foundation, administered by Orthopaedics, 2022-2022 More info
- Investigating the abscopal effect of Immunolight in murine models of melanoma and soft tissue sarcoma in vivo. (Principal Investigator), awarded by Immunolight, LLC, administered by Orthopaedics, 2021-2022 More info
- Development and validation of anti-canine reagents to enable pre-clinical development of novel therapeutics (Principal Investigator), awarded by AvantGen, Inc., administered by Orthopaedics, 2020-2022 More info
- Identifying novel CRM1 inhibitor combination therapies to treat sarcomas (Co-Investigator), awarded by Karyopharm Therapeutics, administered by Medicine, Medical Oncology, 2021-2022 More info
- Utilizing intranasal immunization to induce a cytotoxic T lymphocyte response and reduce metastatic burden in the lung (Collaborator), awarded by National Institutes of Health, administered by Pathology, 2020-2021 More info
- Fresh Tissue Lab (Principal Investigator), awarded by Integrum, Inc, administered by Orthopaedics, 2021-2021 More info
- A Prospective Observational Study of Intraoperative Angiography for Predicting Wound Complications in Irradiated Soft Tissue Sarcoma of the Extremities (Co-Principal Investigator), awarded by Piedmont Orthopedic Foundation, administered by Orthopaedics, 2020-2021 More info
Contact
DUMC Box 3000, Durham, NC 27710
919-684-8111
william.eward@duke.edu