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Clinical Research Unit

The Duke Department of Orthopaedic Surgery’s Clinical Research Unit (CRU) plays a critical role in realizing the mission and vision of Duke Orthopaedics.

The CRU oversees and supports all clinical research projects undertaken by Duke Orthopaedics faculty, and helps investigators access and manage pre- and post-award funding from industry, foundation, and federal sources and develop strong research partnerships across disciplines.

Duke Orthopaedics is enjoying an expansion of our research programs across all areas of expertise, including our core focus areas of engineering; cellular, developmental and genome sciences; whole body kinematics; and population biology.

Clinical research has always been the central focus and strength of our Duke Orthopaedics surgical faculty – and the CRU is instrumental in facilitating and advancing this important work.

Recently, a traditional focus on retrospective review-based projects, driven in part by our residency program, has shifted toward more industry-funded research due to our industry partners’ need to understand the function of medical devices we implant in patients.

The CRU facilitates these partnerships while also striving to grow the Department’s portfolio of federally funded clinical research.

Several Duke Orthopaedics faculty have joint appointments with the Duke Clinical Research Institute, providing enhanced opportunities for cost-effective collaborative research.


CRU in Action: Osteoarthritis

According to the CDC, osteoarthritis (OA) affects 13.9 percent of adults aged 25 years and older and 33.6% of those 65+. OA was the second most expensive diagnosis treated in the U.S. in 2011 for all payers. Duke Orthopaedics is developing a multi-faceted approach to addressing the issues of OA, including:

  • Several studies evaluating the cost-effectiveness of various OA treatments
  • Industry-funded protocols evaluating the outcomes of medical devices used to treat OA
  • Federally funded research to assess the ability of biomarkers to predict progression of arthritis after injury
  • Translation of basic science in the area of post-traumatic arthritis that is moving into clinical trials

Orthopaedic Surgery CRU Faculty and Staff

Steven Olson, MD, Director   
DUMC Box 104002

311 Trent Drive, Office 5289
Durham, NC  27710 
steven.olson@duke.edu
W: 919-668-3000
F: 919-668-2933    
                          

Carrie Killelea, Research Practice Manager    
DUMC Box 104002

311 Trent Drive, Office 5256
Durham, NC  27710
carolyn.killelea@duke.edu
W: 919-681-8778

Peter Pavlis, Financial Practice Manager
DUMC Box 104002

311 Trent Drive, Office 5254
Durham, NC  27710
peter.pavlis@duke.edu
W: 919-681-3360

COORDS/Practice Innovation Unit

Carolyn A. Hutyra, MMCI, Research Program Leader
DUMC Box 104002

311 Trent Drive, Office 5230
Durham, NC 27710
carolyn.hutyra@duke.edu
W: 919-668-8146

 

                                                                                

Arthroplasty

Jennifer Friend, Clinical Research Coordinator, Senior
Duke Medical Plaza Page Road
4709 Creekstone Drive, Suite 200

Durham, NC 27703
jennifer.friend@duke.edu
W: 919-668-4373/919-666-0289

Heather Lancaster, Clinical Research Coordinator I
Duke Medical Plaza Page Road
4709 Creekstone Drive, Suite 200

Durham, NC 27703
heather.lancaster@duke.edu
W: 919-660-9867

Megan McKinnie, Clinical Research Coordinator I
Duke Medical Plaza Page Road
4709 Creekstone Drive, Suite 200

Durham, NC 27703
megan.mckinnie@duke.edu
W: 919-660-5520

Foot & Ankle

Elyse Seckens, Clinical Research Coordinator I
Duke Medical Plaza Page Road

4709 Creekstone Drive, Suite 200
Durham, NC 27703
elyse.seckens@duke.edu
W: 919-668-9175

Hannah Marfia, Clinical Research Coordinator I
Duke Medical Plaza Page Road

4709 Creekstone Drive, Suite 200
Durham, NC 27703
hannah.marfia@duke.edu
W: 919-684-2687

Hand

Carrigan Creech, Clinical Research Coordinator II
Duke Medical Plaza Page Road

4709 Creekstone Drive, Suite 200
Durham, NC 27703
carrigan.creech@duke.edu
W: 919-660-9343

Hip Preservation, Basic Sciences

JaNell Dupree, Clinical Research Coordinator I
DUMC Box 104002

311 Trent Drive, Office 5255
Durham, NC 27710
janell.wylie@duke.edu
W: 919-660-4025

Basic Sciences

Stephanie Thompson, Clinical Research Coordinator I
Medical Sciences Research Building 1
203 Research Drive, Suite 372

Durham, NC 27710
stephanie.d.thompson@duke.edu

W: 919-684-5241

Sports Medicine

Elizabeth Pennington, Nurse Clinician
Duke Sports Science Institute

DUMC Box 3615
3475 Erwin Road
Durham, NC 27705
elizabeth.pennington@duke.edu
W: 919-684-6071

Suzanne Finley, Clinical Research Coordinator II 
Duke Sports Science Institute

DUMC Box 3615
3475 Erwin Road

Durham, NC 27705
suzanne.finley@duke.edu
W: 919-684-5431

Courtney Pyles, Clinical Research Coordinator I
Duke Sports Science Institute

DUMC Box 3615
3475 Erwin Road

Durham, NC 27705
courtney.pyles@duke.edu
W: 919-684-6260

Emily Reinke, PhD
Research Practice Leader Senior
Duke Sports Science Institute

DUMC Box 3615
3475 Erwin Road

Durham, NC 27705
emily.reinke@duke.edu
W: 919-684-8997

Trauma, Oncology, Pediatrics

Cindy Sparrow, Clinical Research Specialist, Senior
DUMC Box 104002

311 Trent Drive, Office 5255
Durham, NC 27710
cynthia.sparrow@duke.edu
W: 919-613-5747

Elizabeth Sachs, Clinical Research Coordinator I
DUMC Box 104002

311 Trent Drive, Office 5255
Durham, NC 27710
elizabeth.sachs@duke.edu
W: 919-660-9849

Practice/Innovation/DSSI

Olivia Manickas-Hill, Clinical Research Specialist, Senior
DUMC Box 104002

311 Trent Drive, Office 5230
Durham, NC 27710
olivia.manickashill@duke.edu
W: 919-660-2504


Resources for Investigators

CITI modules: https://www.citiprogram.org/

DOCR: http://docr.som.duke.edu/

eIRB/IRB: https://irb.duhs.duke.edu/


Research Support Offices

  • Duke Office of Clinical Research (DOCR)
    DOCR supports the Clinical Research Units (CRUs), including all School of Medicine faculty, staff, and students, by developing the navigation, tools, and training for the conduct of clinical research in which Duke serves as an investigative site.
     
  • Duke Office of Research Support (Funding Opportunities)
    Duke’s Office of Research Support provides information on funding sources for research and other scholarly projects.
     
  • Institutional Review Board (IRB)
    The IRB ensures the protection of human research subjects by conducting a scientific and ethical review of research studies while providing leadership and education for the research community.
     
  • Office of Audit, Risk, and Compliance
    The Office of Audit, Risk, and Compliance oversees compliance activities across Duke.
     
  • Office of  Research Contracts (ORC)
    The Office of Research Contracts (ORC) supports Duke University School of Medicine and School of Nursing research and educational efforts by drafting, reviewing, negotiating, signing, and performing certain administrative functions regarding agreements with external industry, non-profit/foundation, and government entities for the funding and conduct of clinical and non-clinical research and CME and non-CME educational programs.  ORC additionally supports all Duke faculty in establishing appropriate documentation for exchanges of research materials, confidential information, data, technical know-how, and equipment in support of research across the University.
     
  • Office of Research Administration (ORA) 
    The Office of Research Administration generates systems for research administration performed at Duke University School of Medicine, Duke University Health System, and Duke University. Among these systems, there are three main database applications that facilitate the management and electronic submission of sponsored research projects.
     
  • Office of Research Support
    This University office, under the guidance of the Vice Provost for Research, oversees several administrative areas for research: the Grants, Contracts, & Compliance group; the Funding Opportunities group; the Office of Human Subjects Protection; and the Office of Export Controls.
     
  • Office of Sponsored Programs (OSP)
    The Office of Sponsored Programs performs the post-award administration of sponsored projects.
     
  • Patient Revenue Management Organization (PRMO) Clinical Trials Billing
    The PRMO provides billing support for research projects and establishes standards for clinical trial billing throughout the institution.